Meta-analysis of the application effect of autologous platelet concentrates as the sole graft for maxillary sinus floor augmentation
Objective To analyze the clinical effects of using autogenous platelet concentrates(APCs)as a sole graft in maxillary sinus floor augmentation(MSFA).Methods The computer search was conducted in PubMed,Web of Sci-ence,Cochrane Library,EMbase,CBM,VIP,CNKI,and Wanfang databases,the time period being from the establish-ment of the databases until July 30,2023.The objective was to identify comparative clinical studies within the context of MSFA,specifically focusing on the simultaneous implantation of APCs as a sole graft(study group)versus the same proce-dure without any other graft materials(control group).The analysis aimed to evaluate the impact of APCs on bone aug-mentation in the maxillary sinus floor,changes in maxillary sinus floor height,implant survival rates,and postoperative complications.The collected data were subjected to Meta-analysis using RevMan 5.4.Results A total of 8 relevant arti-cles were included in the analysis,comprising 6 randomized controlled trials and 2 clinical controlled trials.The Meta-analysis results revealed that at 12 months postoperatively,the study group exhibited significantly greater bone augmenta-tion around the implants,in the vicinity of the implants,and in the far-middle region of the maxillary sinus floor com-pared to the control group.The differences were statistical-ly significant(around implants:MD=0.76 mm,95％CI:0.33-1.19 mm,P＜0.001;near implants:MD=1.27 mm,95％CI:1.01-1.53 mm,P＜0.001;far-middle implants:MD=1.35 mm,95％CI:1.06-1.64 mm,P＜0.001).At 6 and 12 months postoperatively,the study group exhibited less change in maxillary sinus floor height compared to the control group,and the differences were statistically significant(at 6 months postoperatively:MD=0.42 mm,95％CI:0.10-0.74 mm,P=0.01;at 12 months postoperatively:MD=1.86 mm,95％CI:1.40-2.32 mm,P＜0.001).Both groups demonstrated a 100％implant survival rate,and no MSFA-related complications were reported.Conclusion The application of APCs in MSFA can increase bone augmentation in the maxillary sinus floor,slow down the descent of maxillary sinus floor height,and contribute positively to the stability of im-plant retention and efficacy.
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