Research progress on the role of autophagy in peri-implantitis
Peri-implantitis is an inflammatory lesion of the soft and hard tissues surrounding implants,caused by factors such as microbial plaque and occlusal trauma.Its features include mucosal inflammation around the implant,accompa-nied by bone loss,which could lead to implant instability or loss.Currently,peri-implantitis has become a common bio-logical complication following implant surgery,and understanding its pathogenesis is crucial for clinical prevention and treatment of the disease.Autophagy is a highly conserved lysosomal degradation process associated with biological pro-cesses such as bone immunity,microbial infection,inflammation and regeneration.Through this process,cells could di-gest intracellular proteins and organelles,thereby achieving self-renewal or adapting to environmental changes.Insuffi-cient or excessive activation of autophagy could lead to dysfunction of vascular endothelial cells,neutrophils,gingival fi-broblasts,epithelial cells,macrophages,osteoblasts and osteoclasts.The physiological changes in these cells under in-flammatory conditions are related to the occurrence and development of peri-implantitis,suggesting that autophagy might play an important role in peri-implantitis.This article provides a review from a cellular perspective on the potential role of autophagy in the pathogenesis and progression of peri-implantitis,aiming to provide potential targets and research di-rections for the prevention and treatment of peri-implantitis.
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