Objective To investigate the clinical value of contrast-enhanced ultrasound(CEUS)in the early differential diagnosis of diabetic kidney disease(DKD).Methods The clinical data of patients with chronic kidney disease(CKD)hospitalized in Beijing Air Force Medical Center from August 2021 to October 2022 were collected,including the etiology of CKD,ultrasound parameters and laboratory biochemical indicators.The patients were divided into non-DKD group and DKD group.The differences in ultrasound parameters between the two groups were compared and their correlation with clinical indicators were analyze.Results The resistance index(RI)of renal portal artery in DKD group(0.72±0.08)was higher than that in non-DKD group(0.66±0.07)(t=-3.52,P＜0.001),the RI of segmental artery in DKD group(0.67± 0.06)was higher than that in non-DKD group(0.62±0.07)(t=-2.93,P=0.005),and the time to peak(TTP)[(23.37±6.68)s]of contrast medium was longer than that in non-DKD group[(19.57±7.81)s](t=-2.14,P=0.036),while there were no statistically significant differences in RI of interlobar artery and contrast parameters such as arrival time(AT),ascending slope(AS),peak intensity(PI),descending slope(DS),area under curve(AUC)and mean transit time(MTT)(P＞0.05).During the period of eGFR≥60 mU(min·1.73 m2),the RI of renal portal artery(0.70±0.08),segmental artery(0.65±0.06)and interlobar artery(0.61±0.05)in DKD group was significantly higher than that in non-DKD group[(0.62±0.10)(t=-3.30,P＜0.01),(0.59±0.05)(t=-3.29,P＜0.01),(0.56±0.04)(t=-3.05,P＜0.01)].The TTP in DKD group[(23.67±3.75)s]was also significantly longer than that in non-DKD group[(18.80±7.10)s](t=-2.54,P＜0.05).During the period of eGFR＜60 mL/(min·1.73m2),compared with non-DKD group,the RI of renal portal artery in DKD group(0.75±0.06)was higher(t=-2.74,P＜0.01),but there were no differences in RI of segmental artery,RI of interlobar artery,or TTP.Conclusions The TTP combined with RI of segmental artery,interlobar artery,and renal portal artery in CEUS has certain clinical value in the early differential diagnosis of diabetic kidney disease.
diabetic kidney diseasechronic kidney diseasecontrast-enhanced ultrasoundrenal function
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