Objective To determine the relationship between serum uric acid(SUA)and Graves'ophthalmopathy(GO),We conducted a retrospective study in untreated patients with Graves'disease(GD).Methods A total of 154 patients with GD in Jiang Yuan Hospital from Jan.2018 to Sep.2021 who had not taken antithyroid drugs were included in this study.According to the presence or absence of GO,they were divided into the No GO group(M/F 36/47 cases)and the GO group(M/F 35/36 cases).All enrolled patients met the diagnostic criteria of GD and GO.The patients with Hyperuricemia(HUA),gout,and chronic kidney disease were excluded,as well as drugs affecting uric acid metabolism.All enrolled patients required to test thyroid function,TPOAb,TRAb,TgAb,SUA,creatinine,fasting blood glucose,serum lipids,thyroid ultrasound,and orbital CT.Patients with GO underwent a complete eye examination and evaluated CAS score and NONSPECS score.SPSS 22.0 software was used for statistical analysis.Results(1)The CAS score and NONSPECS score and TRAb lerel in the GO group were higher than those in the No GO group(P＜0.05).There were no significant differences in sex ratio,age,hyperthyroidism course,BMI,FT3,FT4,TSH,TPOAb,TgAb,cystein C,blood glucose,BUN and creatinine levels between the two groups.(2)The SUA level in the GO group was higher than that in the No GO group(P＜0.05).There was no significant difference in the proportion of HUA between the two groups.(3)We conducted subgroup analysis according to gender.In the female subgroup,the mean SUA level in the GO group was significantly higher than that in the No GO group(P＜0.05),the proportion of HUA in GO group was significantly higher than that in No GO group(P＜0.05).In the male subgroup,the mean SUA level and the proportion of HUA in GO group were not different from that in No GO group.(4)We found that the presence of GO in female was positively correlated with female SUA(r=0.304,P＜0.05),but not with smoking,FT3,FT4,TRAb,TPOAb and TgAb.(5)With the presence or absence of GO as the dependent variable,and the total duration of GD,smoking status,FT3,FT4,TRAb,and HUA as the independent variables,we found that compared with GD patients without HUA,these female GD patients with HUA had a 3.23 times increased risk of developing GO by binary logistic regression analysis.Conclusion HUA is a new independent risk factor for GO in GD patients,especially in female GD patients.
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