FT4水平及FT4/FT3比值鉴别垂体性甲状腺功能减退和低T3综合征的有效性研究
Efficiency of the FT4 level and FT4/FT3 ratio in distinguishing pituitary hypothyroidism from low T3 syndrome
杨彦娜 1徐子博 2田泽阳 3杨光 3苏婧如 3潘清蓉 4陈哲4
作者信息
- 1. 首都医科大学附属北京电力医院急诊科,北京 100552;首都医科大学附属北京朝阳医院教育处,北京 100020
- 2. 天津医科大学,天津 300203
- 3. 首都医科大学附属北京朝阳医院教育处,北京 100020
- 4. 首都医科大学附属北京朝阳医院内分泌科,北京 100020
- 折叠
摘要
目的 探索游离甲状腺素(FT4)水平及FT4/游离三碘甲腺原氨酸(FT3)比值初步鉴别垂体性甲状腺功能减退(简称甲减)和低T3综合征的有效性.方法 收集2010年8月至2022年1月在北京朝阳医院住院的患者161例,其中垂体性甲减47例、低T3综合征65例、甲状腺功能正常者49例.对比3组患者的FT4水平及FT4/FT3比值的差异,应用ROC曲线分析FT4/FT3比值初步鉴别垂体性甲减和低T3综合征的有效性,并确定最佳临界值.结果 当FT4＜0.82 ng/dL和(或)FT4/FT3比值＜0.45时,诊断垂体性甲减的可能性较大.结论 FT4水平、FT4/FT3比值可以初步鉴别垂体性甲减和低T3综合征.
Abstract
Objective To explore the effectiveness of FT4 level and FT4/FT3 ratio in the differential diagnosis of Pituitary hypothyroidism and low T3 syndrome.Methods From August 2010 to January 2022,clinical data of 161 cases(including 65 cases of low T3 syndrome,47 cases of pituitary hypothyroidism and 49 cases of normal thyroid function)were collected from Beijing Chaoyang Hospital.The differences in FT4 level and FTJFT3 ratio among the three groups were compared.ROC curve analysis was used to analyze the FT4 level and FT4/FT3 ratio to identify the effectiveness of pituitary hypothyroidism and low T3 syndrome,and to determine the best critical value.Results When FT4＜0.82 ng/dL and/or FT4/FT3 ratio＜0.45,the patient was more likely to be with pituitary hypothyroidism.Conclusion FT4 level and FT4/FT3 ratio can preliminarily distinguish pituitary hypothyroidism from low T3 syndrome.
关键词
FT4/FT3比值/垂体性甲状腺功能减退/低T3综合征Key words
FT4/FT3 ratio/pituitary hypothyroidism/low T3 syndrome引用本文复制引用
基金项目
首都卫生发展全科医学与社区卫生科研专项(2024-1Y-002)
首都卫生发展全科医学与社区卫生科研专项(2023-2Y-007)
出版年
2024
国家科技期刊平台
NSTL
万方数据