首页|非透析慢性肾脏病患者睡眠障碍影响因素分析

非透析慢性肾脏病患者睡眠障碍影响因素分析

Analysis of influencing factors of sleep disorders in non-dialysis patients with chronic kidney disease

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原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探讨慢性肾脏病(CKD)患者睡眠障碍情况及其影响因素.方法 收集2022年6月至2023年12月于大连理工大学附属中心医院肾脏内科住院治疗的CKD非透析1～5期患者406例,根据匹兹堡睡眠质量评估量表进行睡眠障碍评价.根据是否发生睡眠障碍将患者分为睡眠正常组(233例)和睡眠障碍组(173例),采用t检验、Mann-Whitney U检验及卡方检验进行组间比较,采用单因素及多因素logistic回归模型分析睡眠障碍相关的影响因素.结果 406例患者中,42.61％的CKD患者患有睡眠障碍.单因素分析结果显示,尿素氮,血肌酐、肾小球滤过率估计值(eGFR)、血钾、焦虑,抑郁及疾病分期是CKD患者睡眠障碍发生的影响因素.多因素logistic回归分析结果提示,血钾(OR=0.568,95％CI0.341～0.948)是睡眠障碍的独立保护因素,焦虑(OR=1.735,95％CI 1.057～2.846)是睡眠障碍的独立危险因素.亚组分析结果显示,焦虑(OR=1.841,95％CI 1.175～2.884)和收缩压(OR=1.034,95％CI 1.005～1.064)分别是CKD 1～3期和CKD4～5期患者睡眠障碍的危险因素.结论 焦虑和较高的收缩压可能是CKD患者发生睡眠障碍的主要危险因素,维持合理的血钾水平可能会降低患者睡眠障碍的患病风险.
Objective To explore the sleep disorders and its influencing factors in patients with chronic kidney disease(CKD).Methods A total of 406 CKD patients with non-dialysis stages 1-5 were collected,who were hospitalized in the Department of Nephrology at Central Hospital of Dalian University of Technology from June 2022 to December 2023.They were evaluated for sleep disorders according to the Pittsburgh Sleep Quality Assessment Scale,and then they were divided into normal sleep group(233 cases)and sleep disorders group(173 cases).The t test,Mann-Whitney U test,and Chi-square test were used for inter-group comparison,and univariate and multivariate logistic regression models were used to analyze the influencing factors of sleep disorders.Results Among the 406 patients,42.61％of CKD patients suffered from sleep disorders.Univariate analysis showed that urea nitrogen,blood creatinine,estimated glomerular filtration rate(eGFR),blood potassium,anxiety,depression,and disease stage were the influencing factors of sleep disorders in CKD patients.Multivariate logistic regression analysis suggested that blood potassium(OR=0.568,95％CI 0.341-0.948)was an independent protective factor for sleep disorders,while anxiety(OR=1.735,95％CI 1.057-2.846)was an independent risk factor for sleep disorders.Subgroup analysis showed that anxiety(OR=1.841,95％CI 1.175-2.884)and systolic blood pressure(OR=1.034,95％CI 1.005-1.064)were risk factors respectively for sleep disorders in patients with CKD stages 1-3 and CKD stages 4-5.Conclusion Anxiety and higher systolic blood pressure may be the main risk factors for sleep disorders in CKD patients,and maintaining reasonable blood potassium levels may reduce the risk of sleep disorders in the patients.

chronic kidney diseasecross-sectional studyinfluencing factorssleep disorders

卢彦、张爽、宋圆圆、王雨、刘书馨

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大连理工大学附属中心医院(大连市中心医院)肾内科,大连市智慧血液净化重点实验室,辽宁大连 116033

慢性肾脏病 横断面研究 影响因素 睡眠障碍

辽宁省应用基础研究计划项目大连市心脏协会医学科学研究项目大连市医学重点专科"登峰计划"大连理工大学附属中心医院(大连市中心医院)肾内科院内自主立项项目大连市医学重点专科"登峰计划"大连理工大学附属中心医院(大连市中心医院)肾内科院内自主立项项目

2023JH2/101300091DHA22172022ZZ2312022ZZ243

2024

10.19538/j.nk2024090106

中国实用内科杂志
中国医师协会,中国实用医学杂志社

中国实用内科杂志

CSTPCD北大核心
影响因子：1.618
ISSN：1005-2194
年,卷(期)：2024.44(9)