血清β-catenin与心房颤动预后关系研究
Study on the relationship between serum β-catenin and the prognosis of atrial fibrillation
张溪林 1王昊 2白英1
作者信息
- 1. 首都医科大学附属北京同仁医院心血管中心,北京 100005
- 2. 北京市糖尿病研究所首都医科大学附属北京同仁医院,北京 100005
- 折叠
摘要
目的 探索血清β-catenin与心房颤动(简称房颤)预后间的关系.方法 收集2021年9月至2024年1月共147例就诊于首都医科大学附属北京同仁医院的房颤患者.年龄平均(70.59±11.03)岁;其中女性59例(40.1％).采用酶联免疫吸附实验(ELISA)检测人血浆β-catenin含量,采用logistic回归研究β-catenin与房颤预后间的关系.结果 在房颤患者中,logistic回归分析显示β-catenin与急性心肌梗死发生风险呈负相关(校正后OR 0.87,95％CI 0.77～0.99,P=0.03);与大出血发生风险呈正相关(校正后OR 1.17,95％CI 1.02～1.35,P=0.03);与卒中和(或)体循环栓塞以及肺栓塞风险无明显相关性.结论 房颤患者血清β-catenin与急性心肌梗死发生风险呈现负相关,与大出血发生风险呈正相关.
Abstract
Objective To explore the relationship between serum β-catenin and the prognosis of AF.Methods A total of 147 AF patients were enrolled,who were treated in Beijing Tongren Hospital from September 2021 to January 2024.The mean age was(70.59±11.03)Univariate and multivariate and there were 59(40.1％)female:59 patients.Serum β-catenin was detected by Enzyme-Linked Immunosorbent Assay(ELISA).The logistic regression were used to explore the relationship between β-catenin and the prognosis of AF.Results The logistic regression analysis showed that serum β-catenin was negatively correlated with the occurrence of AMI(adjusted OR 0.87,95％confidence interval:0.77-0.99,P=0.03)and positively associated with risk of major bleeding(adjusted OR 1.17,95％CI 1.02-1.35,P=0.03),but had no correlation with the occurrence of stroke and/or systematic embolismor,pulmonary embolism.Conclusion Serum β-catenin is negatirely associated with the occurrence of AMI and positirely correlated with the occurrence of major bleeding in the AF patients.
关键词
心房颤动/β-catenin/急性心肌梗死/大出血Key words
atrial fibrillation/β-catenin/acute myocardial infarction/major bleeding引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据