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人和动物肿瘤内细菌的研究现状

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人和动物体内有几万亿个细菌协调着机体的生理过程,影响着宿主的特异性和免疫细胞功能.已经得到证实的是,某些细菌广泛地存在人和动物的各类肿瘤内,对肿瘤微环境的形成、调控肿瘤生长均发挥着重要作用.针对肿瘤内细菌的相关致癌机制取得了较多成果,有望成为检测与治疗肿瘤的新靶点.现对近年来人和动物肿瘤内细菌的相关研究进展加以综述,并展望其应用前景.
Research status of bacteria in human and animal tumors
Trillions of bacteria in humans and animals coordinate the physiological processes of the body and influence host-specific and immune cell functions.It is well established that certain bacte-ria are widely present in various types of tumors in humans and animals and play an important role in the formation of tumor microenvironment and regulation of tumor growth.More results have been obtained on the oncogenic mechanisms associated with bacteria in tumors,which are expected to be new targets for tumor detection and treatment.The purpose of this paper is to review the re-cent research progress of bacteria in human and animal tumors,and to look forward to their appli-cation.

tumor microenvironmentbacteriacanceroncogenic effects

叶彦、于超、郑慧华、杨泞毓、杜崇涛、谢光洪

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吉林大学动物医学学院,吉林 长春 130062

谢博士动物医院,吉林长春 130062

肿瘤微环境 细菌 癌症 致癌作用

国家自然科学基金资助项目

32273075

2024

中国兽医学报
吉林大学

中国兽医学报

CSTPCD北大核心
影响因子:0.702
ISSN:1005-4545
年,卷(期):2024.44(1)
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