TLR7/8 agonists and their potential applications in prevention and treatment of animal diseases
TLR7 and 8 are important pattern recognition receptors(PRRs)in animals,which initi-ate innate immunity and activate adaptive immunity,playing an important role in pathogenic infec-tion.TLR7/8 agonists have the function of enhancing the immune response of the body,activating immune cells,regulating the production of inflammatory cytokines,and are of great significance in accelerating the clearance of pathogens.These ligands are considered to be a potential preventive drug for many diseases and are expected to be used in the treatment of viral infections,tumors and other diseases,or as an immune adjuvant to provide lasting antibody protection for animals.The common TLR7/8 agonists are mostly imidazoquinolines derivatives and nucleoside analogues.Al-though some drugs have entered the clinical research stage,only a few have been approved for clin-ical use.In this paper,TLR7/8 agonists and their potential applications in antiviral and immune ad-juvants are summarized.
TLR 7/8 agonistsimmunoenhancerprevention and control of livestock and poultry dis-easesantivirusadjuvant
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