黄酮类化合物通过circRNAs调控肌肉发育
Regulatory role of flavonoids in muscle development via circRNAs
毛嘉妮 1罗菊 1龚焕焕 1夏银钊 1杨震国2
作者信息
- 1. 西南大学动物科学技术学院生物饲料与分子营养实验室,重庆 400715
- 2. 西南大学动物科学技术学院生物饲料与分子营养实验室,重庆 400715;国家生猪技术创新中心,重庆 402460
- 折叠
摘要
黄酮类化合物作为食物中含量丰富的一类多酚类化合物,具有抗氧化、抗炎抗菌、抗肿瘤等多种生物活性.除了在疾病治疗上发挥作用以外,目前有关于黄酮类化合物在动物机体发育中的研究也有增多.circRNAs作为一种在骨骼肌富集的新型的非编码RNA,在疾病治疗和机体发育上都发挥着作用.近年来,有研究证明了黄酮类化合物能够通过对circRNAs调控进一步对动物机体疾病治疗和发育产生作用,有关于黄酮类化合物和circRNAs之间对动物机体功能的研究也逐渐成为热点.因此,综述黄酮类化合物在肌纤维类型转变、成肌细胞分化增殖等方面对动物肌肉发育的营养调控作用,及circRNAs对动物肌肉发育的影响,并就两者之间在对肌肉发育调控上可能存在的联系进行概述,可为植物提取物和circRNAs的结合研究提供参考,并为黄酮类化合物作为功能性添加剂在畜牧养殖生产中应用提供新的理论支撑.
Abstract
Flavonoids are a class of polyphenols abundant in various food sources,exhibiting numer-ous biological activities such as antioxidation,anti-inflammation,antibacterial effects,and anti-tumor properties.Apart from their potential in disease treatment,recent research has also focused on the impact of flavonoids on animal development.circRNAs,a novel type of non-coding RNAs predominantly found in skeletal muscle,contribute to both disease treatment and body develop-ment.In recent years,studies have demonstrated that flavonoids can modulate the treatment and development of animal diseases by regulating circRNAs.Moreover,investigations on the effects of flavonoids and circRNAs on animal physiological functions have gained significant attention.Hence,this paper provides a comprehensive review of the nutritional influence of flavonoids on ani-mal muscle development,encompassing aspects such as muscle fiber type conversion,myoblast dif-ferentiation and proliferation.Additionally,it explores the impact of circRNAs on animal muscle development and examines the potential relationship between flavonoids and circRNAs in muscle regulation.This study not only serves as a reference for combining plant extracts and circRNAs but also offers novel theoretical support for the application of flavonoids as functional additives in live-stock production.
关键词
骨骼肌/肌肉发育/黄酮类化合物/circRNAsKey words
skeletal muscle/muscle development/flavonoids/circRNAs引用本文复制引用
基金项目
国家生猪技术创新中心先导科技基金(NCTIP-XD/B02)
国家自然科学基金青年科学基金(31902167)
西南大学大学生创新创业训练计划(S202210635347)
重庆市教委科学技术研究项目(NCTIP-XD/B02)
重庆市教委科学技术研究项目(KJQN202200218)
重庆市留学人员回国创业创新支持计划(cx2019093)
出版年
2024
NETL
NSTL
万方数据