摘要
柴胡在中医中的应用已有2 000多年的历史,具有解表、清热、调肝气、升阳气的作用,其药用特性已在欧亚大陆和北非广泛使用.柴胡皂苷(尤其是柴胡皂苷a和柴胡皂苷d)作为柴胡中的主要生物活性化合物,具有抗炎、抗肿瘤、抗氧化、抗病毒、免疫调节和保肝等作用.本文对柴胡皂苷的药理活性、作用机制及应用现状进行综述,以期为柴胡的进一步研究和开发提供新的见解.
Abstract
Radix Bupleuri has been used in traditional Chinese medicine for over 2000 years with functions of relieving exterior syndrome,clearing heat,regulating liver-qi,and lifting yang-qi.Its medicinal properties have been widely used in Eurasia and North Africa.As the main bioactive compounds in Radix Bupleuri,saikosaponins(especially saikosaponin A and saikosaponin D)have anti-inflammatory,anti-tumor,antioxidant,antivirus,immune regulatory,and liver protective effects.This article reviews the pharmacological activity,mechanism of action,and current applica-tion status of saikosaponins,in order to provide new insights for further research and development of Radix Bupleuri.
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