白细胞介素-17在主要细菌性人兽共患病中的作用及其机制
Roles of interleukin-17 in major bacterial zoonoses and its mechanisms
刘爱军 1黄晓兵 1周彩琴 1张传亮1
作者信息
- 1. 浙江省动物疫病预防控制中心,浙江杭州 311199
- 折叠
摘要
白介素-17(IL-17)是重要的促炎细胞因子,能够连接先天性免疫和适应性免疫,介导对病原感染的保护性免疫,然而一旦分泌失调又会促进炎症病理损伤和自身免疫性疾病.在多种细菌性人兽共患病中,IL-17都具有重要的保护作用,促进了各种器官组织炎性疾病的发生发展,并与细菌感染诱导的自身免疫性疾病相关.近期的研究表明,细菌感染中分泌IL-17的CD4+组织驻留记忆T细胞在维持适应性免疫中发挥着关键作用,靶向IL-17反应的疫苗设计策略对于提高疫苗效力具有明显优势.为此,本文综述了 IL-17的生物学功能及其在主要细菌性人兽共患病中的作用和相关机制,以期为开发安全有效的基于IL-17的免疫疗法提供参考.
Abstract
Interleukin-17(IL-17)is an important pro-inflammatory cytokine that bridges innate and adaptive immunity,promoting protective immunity against pathogens,but also driving inflamma-tory pathology during infection and autoimmunity.IL-17 has important protective roles in a variety of bacterial zoonoses,but also promotes the development of inflammatory diseases in various organ tissues and is associated with autoimmune diseases induced by bacterial infections.Recent studies have shown that IL-17-secreting CD4+tissue-resident T memory cells play a key role in sustaining adaptive immunity to bacterial infections,and vaccine design strategies targeting IL-17 responses exhibit apparent advantages in improving vaccine efficacy.In this regard,this paper reviews the bio-logical functions of IL-17 and its roles in major bacterial zoonoses and related mechanisms,with the aim of providing a reference for the development of safe and effective IL-17-based immunother-apies.
关键词
IL-17/细菌/人兽共患病/免疫Key words
IL-17/bacteria/zoonoses/immunity引用本文复制引用
基金项目
浙江省农业重大技术协同推广项目(2021XTTGXM05)
出版年
2024
NETL
NSTL
万方数据