Toll样受体9对原虫的天然免疫识别
Innate immune recognition of protozoon parasites by Toll-like receptor 9
于丽颖 1张乃文 1范芮铭 1张义伟 1姜宁1
作者信息
- 1. 沈阳农业大学动物科学与医学学院辽宁省人兽共患病研究重点实验室/辽宁省人兽共患病研究工程实验室,辽宁沈阳 110866
- 折叠
摘要
先天性免疫系统对病原体的识别作用是宿主保护自身免受微生物入侵的第一道防线.Toll样受体(TLRs)是特征明确的模式识别受体,对病原体相关分子模式(PAMPs)的识别、调节抗原呈递细胞和关键细胞因子的激活至关重要.TLR9对原虫基因组DNA的识别会激活NF-κB、IRF3/7和MAPK等细胞通路,诱导促炎症细胞因子和 Ⅰ型干扰素的产生.在原虫感染中MyD88是TLR9识别PAMPs的关键接头分子,本综述主要总结了 TLR9-MyD88信号途径在几种常见原虫感染期间诱导的炎症反应中的重要性,还讨论了 TLR9的亚细胞定位对原虫感染的影响,以期为进一步理解原虫与宿主相互作用的复杂性,为原虫寄生虫病的防制奠定基础.
Abstract
The recognition of the innate immune system is the first line of defense for host protec-tion against invading microbes.Toll-like receptors(TLRs)are well-characterized pattern recogni-tion receptors that are critical for recognizing pathogen-associated molecular pattern(PAMP)and regulating the activation of antigen-presenting cells and key cytokines.Recognition of protozoon parasite genomic DNA by TLR9 activates transcription factors such as NF-κB,IRF3/7,and MAPK,which then induce the production of pro-inflammatory cytokines and type Ⅰ interferons.During parasite infection,MyD88 serves as a critical adapter protein for TLR9 to recognize PAMPs.Here,we review the TLR9-MyD88 pathways and their importance in the inflammatory re-sponse in some common protozoan parasite infections.We also discuss the impact of the subcellular localization of TLR9 in parasitic infectious diseases.By emphasizing current developments in these fields,the review aims to lay the foundation for future research on both the complexity of host-par-asite interactions and the prevention of protozoan parasitic diseases.
关键词
Toll样受体9/原虫感染/CpG/DNA/疟色素Key words
Toll-like receptor 9/protozoon parasite infection/CpG DNA/hemozoin引用本文复制引用
基金项目
国家自然科学基金面上项目(31972702)
中国医科院人兽共患寄生虫致病机制研究创新单元基金(2019-IM-5-042)
出版年
2024
NETL
NSTL
万方数据