中国兽医学报2024,Vol.44Issue(10) :2294-2300.DOI:10.16303/j.cnki.1005-4545.2024.10.27

猪细小病毒感染引起宿主信号通路变化的研究进展

Research progress on alterations in host signaling pathways triggered by porcine parvovirus infection

周敏 汤德元 曾智勇 王彬 黄涛 胡雯雯 毛茵茗 周飘 何松
中国兽医学报2024,Vol.44Issue(10) :2294-2300.DOI:10.16303/j.cnki.1005-4545.2024.10.27

猪细小病毒感染引起宿主信号通路变化的研究进展

Research progress on alterations in host signaling pathways triggered by porcine parvovirus infection

周敏 1汤德元 1曾智勇 1王彬 1黄涛 1胡雯雯 1毛茵茗 1周飘 1何松1
扫码查看

作者信息

  • 1. 贵州大学动物科学学院,贵州贵阳 550025
  • 折叠

摘要

猪细小病毒(porcine parvovirus,PPV)是猪细小病毒病(porcine parvovirus infection,PPI)的病原体,感染PPV是引起猪繁殖障碍的重要原因,给养猪业带来严重危害.本病临床以妊娠母猪产死胎、木乃伊胎、弱胎和发生流产等为特征,其发病机制尚未被完全了解,且目前尚无有效的治疗药物.近年来,人们已对PPV感染宿主后其信号通路变化做了大量地深入研究,许多相应的信号通路传导机制也已发现,但仍缺乏对其系统性的探究,通过对PPV感染后引起的相关信号通路变化的研究进行综述,以期为研究PPV的致病机制和新型药物开发提供新的思路.

Abstract

Porcine parvovirus(PPV)is a causative agent of porcine parvovirus infection(PPI),which significantly impacts the pig industry due to its association with reproductive dysfunction.The condition is characterized by stillbirth,mummified fetuses,fetal weakness,and abortion in pregnant sows.The pathogenic mechanism remains incompletely understood,with no effective therapeutic drugs available currently.Despite extensive research on the host's response to PPV in-fection and identification of various signaling pathway transduction mechanisms,a comprehensive understanding is still lacking.This review aims to summarize the current knowledge regarding al-terations in related signaling pathways following PPV infection,provide novel insights into the pathogenesis of PPV and facilitate the drug development.

关键词

猪细小病毒/繁殖障碍/信号通路/致病机制

Key words

porcine parvovirus/reproductive disorders/signal pathways/pathogenic mechanism

引用本文复制引用

基金项目

黔科合平台人才资助项目([2018]5781-8)

国家自然科学基金资助项目(31860716)

出版年

2024
中国兽医学报
吉林大学

中国兽医学报

CSTPCDCSCD北大核心
影响因子:0.702
ISSN:1005-4545
参考文献量49
段落导航相关论文