猪圆环病毒2型(porcine circovirus type 2,PCV2)是引起与猪圆环相关疾病的主要病原体,猪感染PCV2后可能导致猪皮炎和肾病综合征(PDNS)以及断乳仔猪多系统衰竭综合征(PMWS)等,目前尚未完全了解其致病机制.PCV2是单股负链环状DNA,会引起机体免疫抑制从而导致继发性易感性升高,与各种猪病产生协同作用,对养猪产业带来重大经济损失,虽然已有商品化疫苗,但疫苗的预防具有一定的局限性且至今尚无有效药物治疗,一旦暴发将威胁人们的生命健康和公共安全,造成重大经济损失.为了解PCV2逃避机制和防控的最新进展,现将对PCV2抑制干扰素产生、调控细胞凋亡、调控细胞自噬、调控细胞焦亡与炎症反应、逃避适应性免疫应答以及PCV2的防控方面进行概述,以期为PCV2的研究及防控提供新的理论思路.
Research progress of immune response mechanisms and prevention and control of porcine circovirus type 2
Porcine circovirus type 2(PCV2)is the main pathogen causing porcine circovirus related diseases.PCV2 infection in pigs may lead to porcine dermatitis and nephrotic syndrome(PDNS)and weaned piglets multiple system failure syndrome(PMWS),etc.At present,the pathogenic mechanism is not fully understood.PCV2 is a single strand of negative link DNA,which can cause immune suppression in the body and lead to increased secondary susceptibility,which has a syner-gistic effect with various pig diseases and brings major economic losses to the pig industry.Al-though there are commercial vaccines,the prevention of vaccines has certain limitations and there is no effective drug treatment so far,an outbreak will threaten people's life and health and public safety,resulting in significant economic losses.In order to understand the latest progress of PCV2 escape mechanism and prevention and control,this paper summarizes the inhibition of interferon production,regulation of apoptosis,regulation of autophagy,regulation of pyroptosis and inflam-matory response,evasion of adaptive immune response,and prevention and control of PCV2,in or-der to provide new theoretical ideas for the research and prevention and control of PCV2.
porcine circovirus type 2signal pathimmune escapeinnate immunityadaptive immu-nity
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