纳米药物治疗鸡球虫病的研究进展
Research progress on nanomedicine for treating chicken coccidiosis
范玉青 1彭树德 2白和平 3史秋梅4
作者信息
- 1. 赵县综合职业技术教育中心,河北 赵县 051530
- 2. 唐山市食品药品综合检验检测中心,河北唐山 063000
- 3. 河北农业大学中兽医学院,河北保定 071000
- 4. 河北科技师范学院,河北省预防兽医学重点实验室,河北秦皇岛 066004
- 折叠
摘要
鸡球虫专门在鸡肠道黏膜上皮细胞内生长繁殖,危害鸡群健康.然而,传统的化学药物很难通过细胞屏障,并且易造成耐药虫株的出现以及兽药残留问题,给球虫病的防控带来巨大的挑战,因此,有必要开发新的抗球虫策略.纳米药物具有生物相容性好、易修饰且效率高等优势,提高细胞膜的穿透性的同时降低了药物的毒副作用,有望应用于球虫病防治.本文介绍了多种抗鸡球虫病的纳米药物,总结了其与传统制剂相比的优点,重点介绍纳米药物在治疗鸡球虫病中的应用,阐述目前纳米药物治疗鸡球虫病仍存在的问题,并对该领域面临的挑战和未来发展方向进行展望,以期为开发用于治疗鸡球虫病的纳米药物提供重要参考.
Abstract
Chicken coccidia specialize in growing and reproducing within the epithelial cells of the chicken intestinal mucosa,posing a threat to the health of the chicken flock.However,traditional chemical drugs are difficult to pass through the cell barrier and can easily lead to the emergence of drug-resistant strains and residual veterinary drugs,posing a huge challenge to the prevention and control of coccidiosis.Therefore,it is necessary to develop new strategies against coccidiosis.Nano-drugs have the advantages of good biocompatibility,easy modification,and high efficiency,impro-ving the penetration of cell membranes while reducing drug toxicity and side effects.They are ex-pected to be applied in the prevention and treatment of coccidiosis.This article introduces various nanomedicines for treating chicken coccidiosis,summarizes their advantages compared to tradition-al formulations,focuses on the application of nanomedicines in the treatment of chicken coccidio-sis,elucidates the existing problems of nanomedicine treatment for chicken coccidiosis,and looks forward to the challenges and future development directions in this field,in order to provide impor-tant references for the development of nanomedicines for treating chicken coccidiosis.
关键词
鸡/球虫病/纳米药物/球虫病防治Key words
chicken/coccidiosis/nanodrugs/prevention and control of coccidiosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据