细胞焦亡在白血病中的研究进展:从机制到治疗
Research Progress of Pyroptosis in Leukemia:from Mechanism to Treatment
周灵艳 1殷小成1
作者信息
- 1. 南华大学衡阳医学院附属第一医院儿科,湖南衡阳 421600
- 折叠
摘要
细胞焦亡是由活化的半胱天冬蛋白酶和Gasdermin家族蛋白(GSDM蛋白)介导的一种程序性死亡形式,具有细胞肿胀、胞膜溶解和炎症因子释放的特点.白血病是以恶性转化的造血干细胞异常分化和增殖为特征,且严重威胁人类健康的恶性疾病.近年来的研究发现,白血病细胞的转化、增殖、转移以及治疗反应都与细胞焦亡密切相关.细胞焦亡为白血病的研究提供一个新视角,本文就细胞焦亡的类型及分子机制、焦亡在白血病中发生发展以及白血病治疗过程中发挥的作用进行综述,为更深入研究细胞焦亡与白血病的关系提供参考,以期为白血病治疗提供新策略.
Abstract
Pyroptosis is a programmed death mediated by activated caspase and Gasdermin family proteins,characterized by cell swelling,cytosolysis and release of inflammatory factors.Leukemia is a malignant disease characterized by abnormal differentiation and proliferation of hematopoietic stem cells,thus seriously threating human health.In recent years,it has been found that the transformation,proliferation,metastasis and treatment response of leukemia cells are closely related to pyrodeath.Pyroptosis provides a new perspective for the study of leukemia.This paper reviews the types and molecular mechanisms of pyroptosis,the role of pyroptosis in the occurrence and development of leukemia and the treatment of leukemia,so as to provide some references for further study of the relationship between pyroptosis and leukemia,in order to provide a new strategy for the treatment of leukemia.
关键词
细胞焦亡/白血病/GSDM蛋白Key words
pyroptosis/leukemia/gasdermin protein引用本文复制引用
基金项目
国家自然科学基金(31271482)
湖南省自然科学基金(20201977)
出版年
2024
NETL
NSTL
维普
万方数据