PI3K/AKT/mTOR信号通路在多发性骨髓瘤中作用机制的研究进展
Research Progress on the Mechanism of PI3K/AKT/mTOR Signa-ling Pathway in Multiple Myeloma
刘青青 1李宜蔷 1程纬民2
作者信息
- 1. 广西中医药大学研究生学院,广西南宁 530001
- 2. 广西中医药大学第一附属医院血液内科,广西南宁 530023
- 折叠
摘要
PI3K/AKT/mTOR信号通路在肿瘤的发生发展、转归预后中具有重要的意义,与多发性骨髓瘤(MM)的发病密切相关.PI3K/AKT/mTOR信号通路可通过多途径、多靶点参与调节MM,如调控MM细胞生存的肿瘤微环境,影响肿瘤发展、迁移,调控MM细胞增殖、凋亡、自噬.研究表明,PI3K/AKT/mTOR信号通路被抑制后,MM细胞的凋亡、自噬被激活,促进MM细胞的死亡,抑制MM细胞的转移及复发.因此,深入研究PI3K/AKT/mTOR信号通路在MM中的作用机制有助于阐明MM的发病机理及转归预后.
Abstract
PI3K/AKT/mTOR signaling pathway is of great significance in the development and prognosis of tumors,and is closely related to the pathogenesis of multiple myeloma(MM).PI3K/AKT/mTOR signaling pathway can participate in the regulation of MM through multi-channel and multi-target,such as regulating the tumor microenvironment of MM cells survival,affecting tumor development and migration,regulating the proliferation,apoptosis and autophagy of MM cells.It have shown that after the PI3K/AKT/mTOR signaling pathway is inhibited,the apoptosis and autophagy of MM cells are activated,which promote the death of MM cells and inhibit the metastasis and recurrence of MM cells.Therefore,in-depth study of the mechanism of PI3K/AKT/mTOR signaling pathway in MM is helpful to elucidate the pathogenesis and prognosis of MM.
关键词
PI3K/AKT/mTOR/多发性骨髓瘤/作用机制Key words
PI3K/AKT/mTOR/multiple myeloma/mechanism of action引用本文复制引用
基金项目
国家自然科学基金地区科学基金(81960839)
出版年
2024
NETL
NSTL
维普
万方数据