IL-6/IL-6R/JAK2/STAT3通路调控骨髓微环境对多发性骨髓瘤生物学行为影响的研究进展
Research Progress on Effect of Bone Marrow Microenvironment Regulated by IL-6/IL-6R/JAK2/STAT3 Pathway on Biological Behavior of Multiple Myeloma
石玉士 1许家威 1刘青青 1李宜蔷 1程纬民2
作者信息
- 1. 广西中医药大学第一临床医学院,广西南宁 530200
- 2. 广西中医药大学第一附属医院血液内科,广西南宁 530023
- 折叠
摘要
多发性骨髓瘤(MM)是一种克隆浆细胞异常增殖的恶性疾病,疾病的发展表现出广泛的异质性,这种异质性与MM肿瘤细胞、骨髓微环境之间的相互作用密切相关.IL-6/IL-6R/JAK2/STAT3通路可以调节骨髓微环境中相关可溶性因子的转录,促进MM肿瘤细胞增殖、抗凋亡、产生耐药性及引导相关骨破坏.本文就IL-6/IL-6R/JAK2/STAT3通路调控骨髓微环境对MM生物学行为影响的研究进展进行综述,以期为MM的靶向治疗及精准治疗提供新的研究思路.
Abstract
Multiple myeloma(MM)is a malignant disease with abnormal proliferation of clonal plasma cells.The development of the disease shows a vast heterogeneity,which is closely related to the interaction between MM cells and bone marrow microenvironment(BMM).The interleukin-6(IL-6)/interleukin-6 receptor(IL-6R)/Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)pathway can regulate the transcription of related soluble factors in BMM,promote the proliferation,anti-apoptosis,drug resistance and guide related bone destruction of MM cells.This article reviews the research progress on the effect of BMM regulated by IL-6/IL-6R/JAK2/STAT3 pathway on the biological behavior of MM,in order to provide new research ideas for targeted therapy and precise therapy of MM.
关键词
多发性骨髓瘤/骨髓微环境/白介素-6/白介素-6受体/Janus激酶2/信号转导和转录活化蛋白3Key words
multiple myeloma/bone marrow microenvironment/interleukin-6/interleukin-6 receptor/Janus kinase 2/signal transducer and activator of transcription 3引用本文复制引用
基金项目
国家自然科学基金地区科学基金(81960839)
出版年
2024
NETL
NSTL
维普
万方数据