Chronic lymphocytic leukemia(CLL)/small lymphocytic lymphoma(SLL)is a relatively inert B lymphocyte proliferative disease.In recent years with the launch of new drugs,chemotherapy has been gradually replaced by targeted therapy,which significantly prolongs the survival of patients and reduces the side effects of treatment.At present,BTK inhibitors,PI3K inhibitors,spleen tyrosine kinase(SYK)inhibitors and BCL-2 inhibitors are the most studied targeted therapeutic drugs for CLL/SLL.This article reviews the research progress of different types of targeted therapeutic drugs in the treatment of CLL/SLL.
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