长链非编码RNA在急性髓细胞白血病发生发展中作用的研究进展
Research Progress on Role of Long Non-Coding RNA in Occurrence and Development of Acute Myeloid Leukemia——Review
卢晓诗 1王薪祺 1杜英男 1张继红2
作者信息
- 1. 中国医科大学第四临床学院,辽宁沈阳 110122
- 2. 中国医科大学附属盛京医院血液研究室,辽宁沈阳 110004
- 折叠
摘要
近年来,长链非编码RNA(lncRNA)在急性髓细胞白血病(AML)中的重要性引起人们的广泛关注,其中发挥促癌作用的lncRNA 主要有HOTAIR、UCA1、H19、ITGB2-AS1和SNHG家族的部分基因,而起抑癌作用的lncRNA主要有H22954、NEAT1、SNHG4、LINC01128等.本文就lncRNA在AML发生发展中的作用以及与AML耐药和预后判断相关的lncRNA进行综述,以期为AML的诊断和预后分析提供理论依据.
Abstract
In recent years,the importance of long non-coding RNA(lncRNA)in acute myeloid leukemia(AML)has attracted wide attention.Among them,lncRNAs that play a role in promoting cancer mainly include HOTAIR,UCA1,H19,ITGB2-AS1 and some genes of SNHG family,while in tumor suppression mainly include H22954,NEAT1,SNHG4,LINC01128,etc.This article reviews the role of lncRNAs in the occurrence and development of AML,as well as those related to AML resistance and prognosis assessment,so as to provide a theoretical basis for the diagnosis and prognosis analysis of AML.
关键词
急性髓细胞白血病/长链非编码RNA/促癌/抑癌/耐药/预后Key words
acute myeloid leukemia/long non-coding RNA/tumor promoter/tumor suppressor/drug resistance/prognosis引用本文复制引用
基金项目
国家自然科学基金青年基金(8220027)
国家自然科学基金(82070165)
出版年
2024
NETL
NSTL
维普
万方数据