Research Progress on the Role of Autophagy Pathway in the Pharmacological Treatment of Multiple Myeloma——Review
Multiple myeloma(MM)is a malignant hematological tumour for which pharmacological treatments such as protease inhibitors,immunomodulators,and steroids are commonly used,but most MM cases still relapsed or become refractory.Autophagy is a type 2 cell death mechanism that plays a key role in MM progression,including biphasic regulation that promotes MM cell survival or facilitates its death.In this paper,we review the changes of MM cells'autophagic activity and its effect on cell proliferation and apoptosis during drug action,aiming to analyse the role of autophagy pathway in drug treatment of MM and provide relevant ideas for targeting autophagy in the treatment of MM.
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