Research Advances in Strategies to Enhance the Therapeutic Effects of Mesenchymal Stem Cells on Graft-Versus-Host Disease Post Hematopoietic Stem Cell Transplantation——Review
Research Advances in Strategies to Enhance the Therapeutic Effects of Mesenchymal Stem Cells on Graft-Versus-Host Disease Post Hematopoietic Stem Cell Transplantation——Review
Mesenchymal stem cells (MSC) possess unique immunomodulatory properties and have enormous potential in the treatment of graft-versus-host disease (GVHD). However,the low implantation and survival rates of MSC in vivo,coupled with their weak immunosuppressive functions,have resulted in unstable clinical efficacy in the treatment of GVHD. Preconditioning of MSC with hypoxia,active molecules and gene modification can enhance the function of MSC and improve the implantation rate,survival rate and therapeutic effect of MSC. This review summarized the strategies for enhancing the efficacy of MSC in the treatment of hematopoietic stem cell transplantation complicated with GVHD in recent years,aiming to provide new strategies for optimizing the application of MSC in the prevention and treatment of GVHD.
关键词
造血干细胞移植/移植物抗宿主病/间充质干细胞/增效策略
Key words
hematopoietic stem cell transplantation/graft-versus-host disease/mesenchymal stem cells/strategies for enhancing the efficacy
维普
万方数据