Effect of high-frequency repetitive transcranial magnetic stimulation on dysphagia in cerebral infarction and its mechanism study
Objective To observe the effect of high-frequency repetitive transcranial magnetic stimulation(rTMS)on dysphagia in patients with cerebral infarction and to explore its possible mechanism.Methods 10 dysphagia patients after unilateral cerebral cerebral infarction were selected,and 5 Hz high-frequency rTMS was used to stimulate the cerebral cortical motor representative area of the mylohyoid muscle group in the affected cerebral hemisphere.Before and 2 weeks after treatment,the swallowing function of the patients was evaluated by standard swallowing assessment(SSA)and video fluoroscopic swallowing study(VFSS),and the swallowing function of patients in case group was compared before and after treatment.In addition,11 healthy volunteers were selected as healthy group.All subjects underwent fMRI examination.The amplitude of low-frequency fluctuations(ALFF)was compared between case group before and after treatment and healthy group.Results After treatment,SSA score in the case group was(20.60±2.20)points,which was lower than that of(24.70±2.93)points before treatment,and the difference was statistically significant(t=3.539,P=0.002<0.05).After treatment,the VFSS score in the case group was(8.20±0.60)points,which was higher than that of(7.10±0.83)points before treatment,and the difference was statistically significant(t=3.396,P=0.003<0.05).Before treatment,the ALFF of the anterior central gyrus and supplementary motor area of the affected hemisphere were weaker than those of healthy group,and the difference was statistically significant(P<0.05).After treatment,the ALFF of the anterior central gyrus and supplementary motor area were higher than those before treatment,and the difference was statistically significant(P<0.05).Conclusion The effect of 5 Hz high-frequency rTMS on the representative region of mylohyoid cortex in the affected cerebral hemisphere can effectively improve the swallowing function of patients with cerebral infarction,and the potential recovery mechanism may be related to the regulation of cerebral cortex excitability.
High-frequencyRepetitive transcranial magnetic stimulationCerebral infarctionDysphagiaMagnetic resonance
NETL
NSTL
万方数据
维普
