Effect of linezolid combined with cycloserine capsule in the treatment of pulmonary tuberculosis and its influence on respiratory function,immune cells and X-pert MTB/RIF results
Objective To explore the effect of the combination of linezolid and cycloserine capsules in the treatment of pulmonary tuberculosis and its influence on respiratory function,immune cells and X-pert MTB/RIF results.Methods A total of 100 patients with pulmonary tuberculosis were divided into a control group and an observation group by random number table method,with 50 cases in each group.Linezolid was used alone in the control group,and linezolid and cycloserine capsules were used in the observation group.The therapeutic effect,respiratory function indicators[forced vital capacity(FVC),forced expiratory volume in one second as a percentage of the predicted value(FEV1%),and ratio of FEV1 to forced vital capacity(FEV1/FVC)],immune cell level,positive rate of acid fast staining and X-pert MTB/RIF and time of symptom improvement were compared between the two groups.Results(i)The total effective rate of the observation group was 96.00%,which was significantly higher than that of 84.00%of the control group,and the difference was statistically significant(P<0.05).(ii)After treatment,FVC,FEV1 and FEV1/FVC in both groups were higher than those before treatment in this group;the observation group had FVC of(1.98±0.28)L,FEV1%of(69.73±7.58)%and FEV1/FVC of(71.04±6.25)%,which were higher than those of(1.58±0.25)L,(58.37±5.64)%and(61.22±4.38)%in the control group;the difference was statistically significant(P<0.05).(iii)After treatment,CD4+ and CD4+/CD8+ in both groups were higher than those before treatment in this group,and CD8+ was lower than that before treatment in this group;CD4+ of(38.24±2.75)%and CD4+/CD8+ of(1.72±0.15)in the observation group were higher than those of(34.74±3.18)%and(1.33±0.26)in the control group;CD8+ of(23.73±1.58)%in the observation group was lower than that of(26.37±1.64)%in the control group;the difference was statistically significant(P<0.05).(iv)After 2 months of treatment,the positive rates of acid fast staining and X-pert MTB/RIF in the observation group were 10.00%and 12.00%,respectively,which were lower than those of 26.00%and 28.00%in the control group,and the difference was statistically significant(P<0.05).(v)The sputum culture negative time,acid-fast staining smear negative time,cavity closing time,focus absorption and reduction time in the observation group were(43.75±7.13),(72.83±10.48),(98.57±12.57)and(38.99±6.13)d,which were shorter than those of(61.23±8.93),(86.79±15.13),(152.19±25.55)and(46.90±7.82)d in the control group,and the difference was statistically significant(P<0.05).Conclusion Linezolid combined with cycloserine capsule has a prominent clinical effect in the treatment of patients with pulmonary tuberculosis.It can improve the respiratory function and immune cell level of patients,reduce the positive rate of acid fast staining and X-pert MTB/RIF of patients,and is beneficial to the improvement of symptoms of patients.It is worth popularizing and applying.
NETL
NSTL
万方数据
维普
