Effects of thoracoscopic surgery on lung function and inflammatory factors in middle-aged and elderly patients with non-small cell lung cancer
Objective To explore the effect of thoracoscopic surgery on lung function and inflammatory factors in middle-aged and elderly patients with non-small cell lung cancer.Methods A total of 120 middle-aged and elderly patients with non-small cell lung cancer were selected.According to the grouping method of random number table,the patients were divided into an observation group and a control group,with 60 cases in each group.The observation group was treated with thoracoscopic surgery,and the control group was treated with traditional thoracotomy.The relevant indicators,forced vital capacity as a percentage of the predicted value(FVC%),forced expiratory volume in one second as a percentage of the predicted value(FEV1%)before surgery and at 1,7 d after surgery,inflammatory factor levels before surgery and at 1,7 d after surgery,and complication rate were compared between the two groups.Results In the observation group,the operative time was(175.46±34.62)min,the thoracic drainage time was(2.97±0.24)d and the hospitalization time was(7.53±0.41)d,which were shorter than those of(190.82±35.54)min,(3.11±0.35)d and(7.69±0.45)d in the control group;the bleeding volume of(102.36±26.47)ml was less that of(113.58±26.14)ml in the control group;the difference was statistically significant(P<0.05).At 7 d after surgery,FEV1%and FVC%in the two groups were significantly decreased compared to those before surgery;FVC%of(73.39±1.25)%and FEV1%of(73.14±1.28)%in the observation group were higher than those of(72.81±1.24)%and(72.52±1.36)%in the control group;the difference was statistically significant(P<0.05).At 1 and 7 d after surgery,the C-reactive protein(CRP)and interleukin-6(IL-6)in both groups were higher than those before surgery;at 7 d after surgery,the CRP and IL-6 were lower than those at 1 d after surgery;the CRP and IL-6 in the observation group at 1 and 7 d after surgery were lower than those in the control group;the difference was statistically significant(P<0.05).The incidence of complications of 6.67%in the observation group was lower than that of 20.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Thoracoscopic surgery for middle-aged and elderly patients with non-small cell lung cancer can reduce the bleeding volume,shorten the operative time,hospitalization time and thoracic drainage time,better recover the patient's lung function,and reduce the occurrence of postoperative inflammatory reaction and complications.
Thoracoscopic surgeryMiddle-aged and elderlyNon-small cell lung cancerLung functionInflammatory factor
NETL
NSTL
万方数据
维普
