Study on clinical efficacy and safety of different doses of gamma globulin in the treatment of children with idiopathic thrombocytopenic purpura
Objective To investigate the clinical efficacy and safety of different doses of gamma globulin in the treatment of idiopathic thrombocytopenic purpura(ITP)in children.Methods 84 patients with ITP were divided into an observation group and a control group by random number table method,with 42 patients in each group.The control group was treated with dexamethasone + high-dose gamma globulin,and the observation group was treated with dexamethasone + low-dose gamma globulin.The clinical efficacy,platelet parameters,immune function and inflammatory factor level before and after treatment,recovery,and adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group(90.48%)and control group(95.24%)was compared,and the difference was not statistically significant(P>0.05).After treatment,the plateletcrit(PCT),platelet count(PLT),platelet distribution width(PDW),mean platelet volume(MPV)of the two groups were higher than those before treatment,and the difference was statistically significant(P<0.05).After treatment,PCT,PLT,PDW and MPV were compared between the two groups,and the difference was not statistically significant(P>0.05).After treatment,the immunoglobulin(Ig)G,IgM and IgA were higher than those before treatment,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in IgG,IgM and IgA between the two groups(P>0.05).After treatment,the tumor necrosis factor-α(TNF-α),interleukin(IL)-4 and IL-6 of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in of TNF-α,IL-4 and IL-6 between the two groups(P>0.05).The PLT recovery time and bleeding stop time of the two groups were not statistically significant(P>0.05).The incidence of adverse reactions in the observation group was 4.76%,which had no statistically significant difference compared with 9.52%in the control group(P>0.05).Conclusion The therapeutic effect of different doses of gamma globulin in children with ITP is equivalent,and both can improve platelet parameters and immune function,and reduce levels of TNF-α,IL-4 and IL-6,promote the recovery of disease,and the safety is good.However,low-dose gamma globulin can significantly reduce the medical burden,which is more worthy of promotion.
NETL
NSTL
万方数据
维普
