生存素及血管内皮生长因子表达与反复自然流产的关系探讨
Correlation between expression of survivin and vascular endothelial growth factor with recurrent spontaneous abortion
黄铸 1张慧芬1
作者信息
摘要
目的 探讨生存素及血管内皮生长因子表达与反复自然流产的关系.方法 选择 60 例反复自然流产患者作为观察组,同期 60 例人工流产患者作为对照组.对两组绒毛组织及血清中生存素及血管内皮生长因子表达进行测定.比较两组血清生存素及血管内皮生长因子表达水平,绒毛组织生存素及血管内皮生长因子阳性率.结果 观察组血清生存素、血管内皮生长因子表达水平分别为(12.40±4.42)、(11.43±4.09)pg/ml,低于对照组的(18.75±2.49)、(18.06±3.41)pg/ml,差异具有统计学意义(P<0.05).观察组绒毛组织生存素、血管内皮生长因子阳性率分别为 31.67%、35.00%,均低于对照组的73.33%、76.67%,差异具有统计学意义(P<0.05).结论 反复自然流产患者的绒毛组织中生存素及血管内皮生长因子阳性率低于健康人,且血清中生存素及血管内皮生长因子表达水平低于健康人,生存素及血管内皮生长因子可能在反复自然流产的发生及发展中具有重要作用.
Abstract
Objective To investigate the correlation of the expression of survivin and vascular endothelial growth factor with recurrent spontaneous abortion.Methods A total of 60 patients with recurrent spontaneous abortion were enrolled in the observation group,and 60 patients with induced abortion were enrolled in the control group.The expressions of survivin and vascular endothelial growth factor in serum and villus tissue of the two groups were measured.The expressions of serum survivin and vascular endothelial growth factor,the positive rates of survivin and vascular endothelial growth factor in villi tissue were compared between the two groups.Results The expressions of serum survivin and vascular endothelial growth factor in the observation group were(12.40±4.42)and(11.43±4.09)pg/ml,which were lower than those of(18.75±2.49)and(18.06±3.41)pg/ml in the control group,and the difference was statistically significant(P<0.05).The positive rate of survivin and vascular endothelial growth factor in villus tissue of the observation group were 31.67%and 35.00%,which were lower than those of 73.33%and 76.67%of the control group,and the difference was statistically significant(P<0.05).Conclusion The positive rate of survivin and vascular endothelial growth factor in villus tissue of patients with recurrent spontaneous abortion is lower than that in healthy people,and the expression of serum survivin and vascular endothelial growth factor in patients with recurrent spontaneous abortion is lower than that in healthy people.Survivin and vascular endothelial growth factor may play an important role in the occurrence and development of recurrent spontaneous abortion.
关键词
反复自然流产/生存素/血管内皮生长因子/血清/绒毛组织Key words
Recurrent spontaneous abortion/Survivin/Vascular endothelial growth factor/Serum/Villous tissue引用本文复制引用
基金项目
深圳市福田区卫生健康系统科研项目(FTWS-2018038)
出版年
2024
NETL
NSTL
维普
万方数据