Analysis of the correlation of age with bone density and osteoporosis in females,and the influencing factors of osteoporosis occurrence
Objective To analyze of the correlation of age with bone density and osteoporosis in females,and the influencing factors of osteoporosis occurrence.Methods 215 female health examination subjects were divided into youth group(≤44 years old,59 cases),middle-aged group(45-59 years old,94 cases),and old group(≥60 years old,62 cases).The bone mineral density of lumbar vertebrae 1-4,femoral neck bone mineral density and occurrence of osteoporosis of the three groups were compared;basic clinical data{education level,body mass index(BMI),alcohol abuse,family history of osteoporosis,serum 25-hydroxyvitamin D[25(OH)D]levels,appendicular skeletal muscle mass index(ASMI),Helicobacter pylori(Hp)infection,Pittsburgh sleep quality index(PSQI)}were compared between subjects with and without osteoporosis.Logistic regression analysis was used to find out the influencing factors of osteoporosis in women.Results The bone mineral density of lumbar vertebrae 1-4,femoral neck bone mineral density in the elderly group were(0.95±0.10)and(0.76±0.08)g/cm2,which were significantly lower than the middle-aged group[(1.04±0.13)and(0.93±0.10)g/cm2],and the youth group[(1.09±0.16)and(1.02±0.12)g/cm2];and the middle-aged group was lower than the youth group;the difference was statistically significant(P<0.05).Among the 215 subjects,31 cases had osteoporosis,accounting for 14.42%.The incidence of osteoporosis in the old group was 30.65%(19/62),which was significantly higher than the youth group[6.78%(4/59)]and the middle-aged group[8.51%(8/94)],the difference was statistically significant(χ2=18.678,P<0.05).In women with osteoporosis,BMI was(21.88±1.39)kg/m2,serum 25(OH)D level was(13.59±1.45)mmol/L,ASMI was(5.36±0.58)kg/m2,which were lower than those without osteoporosis[(23.86±1.17)kg/m2,(16.24±1.71)mmol/L,(6.41±0.72)kg/m2];the proportion of Hp infection of 83.87%in women with osteoporosis was higher than that of 59.78%in women without osteoporosis;the difference was statistically significant(P<0.05).There was no statistically significant difference in education level,alcohol abuse,family history of osteoporosis,and PSQI score between women with and without osteoporosis(P>0.05).Logistic regression analysis showed that Hp infection was a risk factor for osteoporosis in women(OR>1,P<0.05),and high BMI,serum 25(OH)D level and ASMI level were protective factors for osteoporosis in women(OR<1,P<0.05).Conclusion Elderly women have lower bone mineral density and higher risk of osteoporosis,and BMI,serum 25(OH)D level,ASMI,and Hp infection are the influencing factors of osteoporosis in women.Therefore,targeted,scientific and reasonable intervention measures can be proposed to reduce the occurrence of osteoporosis in women.
Bone mineral densityOsteoporosisBody mass index25-hydroxyvitamin DHelicobacter pylori infection
NETL
NSTL
万方数据
维普
