Effect analysis of atorvastatin combined with valsartan in the treatment of patients with coronary heart disease
Objective To investigate the clinical effect of atorvastatin combined with valsartan in the treatment of patients with coronary heart disease.Methods 100 patients with coronary heart disease were divided into a control group and an observation group by random number table,with 50 cases in each group.The control group was treated with valsartan,observation group was treated with atorvastatin and valsartan.Both groups were compared in terms of treatment effect,the occurrence of adverse reactions,the improvement of lipoprotein-associated phospholipase A2(Lp-PLA2),cardiac function index and blood lipid index before and after treatment.Results The total effective rate of 96.00%in the observation group was higher than that of 84.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of Lp-PLA2 in both groups was lower than that before treatment,and the Lp-PLA2 level of(20.76±3.93)g/L in the observation group was lower than that of(36.34±4.42)g/L in the control group.The difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the two groups was higher than that before treatment,and left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were lower than those before treatment;LVEF of(49.89±3.07)%in the observation group was greater than that of(46.26±3.22)%in the control group;LVEDD of(51.83±3.66)mm and LVESD of(35.87±3.41)mm in the observation group were smaller than those of(56.28±3.78)and(39.72±3.30)mm in the control group;the difference was statistically significant(P<0.05).After treatment,the levels of total cholesterol,triglyceride and low density lipoprotein cholesterol in both groups were lower than those before treatment,and the level of high density lipoprotein cholesterol was higher than that before treatment;the total cholesterol in the observation group was(5.22±1.04)mmol/L,the triglyceride was(1.57±0.08)mmol/L and the low density lipoprotein cholesterol was(3.02±1.46)mmol/L,which were lower than those of(6.09±1.43),(2.24±0.23)and(4.23±1.07)mmol/L in the control group;the high density lipoprotein cholesterol(HDL-C)of(1.40±0.29)mmol/L in the observation group was higher than that of(0.99±0.05)mmol/L in the control group;the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Atorvastatin combined with valsartan can play a good effect in the treatment of coronary heart disease,which can improve the plaque stability,heart function and blood lipid indexes of patients,and has high safety,so it is recommended to be widely used in clinical practice.
NETL
NSTL
万方数据
维普
