Study on effect of butylphthalide and urinary kallidinogenase in the treatment of large-artery atherosclerotic stroke patients
Objective To explore and compare the therapeutic effects of butylphthalide and urinary kallidinogenase in the treatment of large-artery atherosclerotic stroke patients.Methods A total of 114 patients with large-artery atherosclerotic stroke were randomly divided into butylphthalide group,urinary kallidinogenase group and combination group,with 38 cases in each group.Butylphthalide group was treated with butylphthalide,and urinary kallidinogenase group was treated with urinary kallidinogenase,and combination group was treated with butylphthalide and urinary kallidinogenase.Comparison was made on National Institute Health Stroke Scale(NIHSS)score at different time points,inflammatory index[level of hypersensitive C-reactive protein(hs-CRP),platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR)]before and after treatment,and the occurrence of adverse reactions among the three groups.Results Before treatment,the NIHSS scores of butylphthalide group,urinary kallidinogenase group and combination group were(24.43±4.88),(24.13±4.95)and(24.36±4.89)points,respectively.On the 15th day of treatment,the NIHSS scores of butylphthalide group,urinary kallidinogenase group and combination group were(20.33±4.21),(20.26±4.17)and(18.12±3.88)points,respectively.On the 15th day of treatment,the NIHSS scores of butylphthalide group,urinary kallidinogenase group and combination group were(18.12±3.77),(17.56±3.98)and(14.02±3.25)points,respectively.Before treatment,there was no significant difference in NIHSS score among the three groups(P>0.05).On the 7th and 15th day of treatment,the NIHSS score of the three groups decreased compared with that before treatment,and the difference was statistically significant(P<0.05).On the 7th and 15th day of treatment,there was no significant difference in NIHSS score between butylphthalide group and urinary kallidinogenase group(P>0.05).On the 7th and 15th day of treatment,the NIHSS score in combination group was lower than that in butylphthalide group and urinary kallidinogenase group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in hs-CPR,NLR and PLR among the three groups(P>0.05).After treatment,the hs-CRP,NLR and PLR in three groups were decreased compared with those before treatment,and the differences were statistically significant(P<0.05).After treatment,the hs-CRP,NLR and PLR in butylphthalide group were lower than those in urinary kallidinogenase group,and the hs-CRP,NLR and PLR in combination group were lower than those in butylphthalide group and urinary kallidinogenase group.The difference was statistically significant(P<0.05).Adverse reactions such as abdominal discomfort,rash,dizziness and fatigue occurred in all the three groups during treatment,and there was no statistical significance among the three groups(P>0.05).No hallucination,palpitation,skin bleeding or intracranial hemorrhage were observed in the three groups.Conclusion Both butylphthalide and urinary kallidinogenase have definite effects on large-artery atherosclerosis,among which butylphthalide has a stronger ability to reduce inflammation in patients,and the combination of the two drugs has a stronger therapeutic effect than that of the drugs alone,which is more favorable to improving the prognosis of the patients.
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维普
