Effect observation of nutritional intervention on nutritional level of non-small cell lung cancer patients during chemotherapy
Objective To discuss the effect of nutritional intervention on nutritional level of non-small cell lung cancer(NSCLC)patients during chemotherapy.Methods 98 patients with non-small cell lung cancer were selected as the study subjects.They were randomly divided into a study group and a control group,with 49 cases in each group.The control group was given conventional intervention,while the study group was given exercise intervention and nutrition intervention.Biochemical indices,body weight and body mass index were compared between the two groups.Results Before chemotherapy and from the 2nd to the 4th cycle of chemotherapy,the white blood cell count in the control group were(6.41±2.69)×109/L,(6.28±3.44)×109/L,(5.23±1.20)×109/L,(5.21±1.27)×109/L,(4.06±2.36)×109/L;the absolute values of neutrophils were(4.39±2.30)×109/L,(4.30±2.05)×109/L,(4.10±0.33)×109/L,(3.77±0.46)×109/L,(3.36±1.28)×109/L;the absolute values of total lymphocytes were(1.42±0.66)×109/L,(1.34±0.72)×109/L,(1.00±0.68)×109/L,(1.00±0.46)×109/L,(0.98±0.33)×109/L;the platelet count were(221.22±90.93)×109/L,(215.98±90.23)×109/L,(202.39±21.12)×109/L,(192.60±32.76)×109/L,(187.44±15.69)×109/L;the hemoglobin were(121.20±25.16),(120.34±16.68),(112.23±15.12),(108.30±16.20),(103.98±14.25)g/L;the total protein were(65.33±4.35),(65.58±5.66),(60.65±6.75),(58.89±5.69),(57.34±6.23)g/L;the albumin were(44.36±5.24),(43.88±5.79),(39.03±6.75),(37.85±5.69),(26.31±6.28)g/L,respectively.In the study group,the white blood cell count were(6.20±2.36)×109/L,(6.88±5.64)×109/L,(5.95±1.45)×109/L,(5.79±1.56)×109/L,(5.63±4.36)×109/L;the absolute values of neutrophils were(4.35±2.56)×109/L,(4.86±5.36)×109/L,(4.30±0.56)×109/L,(4.12±0.34)×109/L,(3.90±1.30)×109/L;the absolute values of total lymphocytes were(1.44±0.86)×109/L,(1.46±0.77)×109/L,(1.33±0.68)×109/L,(1.26±0.77)×109/L,(1.14±0.42)×109/L;the platelet count were(224.12±94.23)×109/L,(222.20±82.59)×109/L,(220.19±33.31)×109/L,(205.43±25.33)×109/L,(197.20±24.26)×109/L;the hemoglobin were(123.55±23.95),(122.26±21.98),(119.24±15.23),(116.20±22.13),(114.01±20.46)g/L;the total protein were(65.12±4.76),(65.68±5.26),(63.45±5.06),(61.30±4.03),(60.11±4.82)g/L;the albumin were(43.25±6.69),(44.98±6.27),(41.65±6.03),(40.20±5.03),(39.25±6.03)g/L.There was no statistically significant difference between the two groups in terms of white blood cell count,absolute value of neutrophils,absolute value of total lymphocytes,platelet count,hemoglobin,total protein,albumin before and during the first cycle of chemotherapy(P>0.05).From the 2nd to the 4th cycle,the white blood cell count,absolute value of neutrophils,absolute value of total lymphocytes,platelet count,hemoglobin,total protein,albumin of the study group were better than those of the control group,with a statistically significant difference(P<0.05).Before chemotherapy and from the 1st to 4th cycles of chemotherapy,the body weight in the control group were(65.02±11.34),(65.29±11.26),(61.00±7.26),(59.03±9.36),(58.69±8.46)kg;the body mass index were(23.56±2.99),(23.87±2.11),(22.26±2.29),(21.16±2.59),(21.06±2.21)kg/m2.In the study group,the body weight were(65.30±10.58),(65.29±10.75),(64.55±10.06),(63.88±10.74),(62.56±9.20)kg;the body mass index were(23.56±2.96),(23.54±2.75),(23.41±2.48),(23.01±2.45),(22.12±2.05)kg/m2.There was no statistically significant difference in body weight and body mass index between the two groups before and during the first cycle of chemotherapy(P>0.05).From the 2nd to the 4th cycle of chemotherapy,the body weight and body mass index in the study group were better than those in the control group,with a statistically significant difference(P<0.05).Conclusion Nutritional intervention has certain clinical value on the nutritional level of patients with non-small cell lung cancer during chemotherapy,and is worthy of extensive promotion and application.
万方数据
维普
