Clinical efficacy of calcitriol combined with cinacalcet in the treatment of uremia with hyperparathyroidism
Objective To analyze the clinical efficacy of calcitriol combined with cinacalcet in the treatment of uremia with hyperparathyroidism.Methods 104 patients with uremia combined with hyperparathyroidism method who received treatment were divided into an observation group and a control group by envelope drawing method,with 52 cases in each group.The control group was treated with calcitriol,while the observation group was treated with calcitriol combined with cinacalcet.Comparison was made on renal function indicators(urea nitrogen,serum creatinine),volume of parathyroid glands,parathyroid hormone,blood phosphorus,blood calcium,and vascular calcification(cardiac valve calcification rate,coronary artery calcium score)before and after treatment,clinical efficacy after treatment and incidence of adverse reactions during medication between the two groups.Results Before and after treatment,there was no significant difference in urea nitrogen and blood creatinine levels between the two groups(P>0.05).After treatment,the volume of parathyroid glands,parathyroid hormone,blood phosphorus,and blood calcium in the observation group were(1.15±0.15)cm3,(287.64±54.32)ng/L,(1.66±0.23)mmol/L and(2.12±0.16)mmol/L.The volume of parathyroid glands reduced,and the parathyroid hormone,blood phosphorus,and blood calcium levels all decreased,which were all smaller than the control group's(1.34±0.22)cm3,(361.68±62.49)ng/L,(2.20±0.31)mmol/L and(2.43±0.29)mmol/L,with a significant difference(P<0.05).The volume of parathyroid glands reduced,and the level of parathyroid hormone decreased in the control group after treatment,with a significant difference(P<0.05).After treatment,the cardiac valve calcification rate of 42.31％and coronary artery calcium score of(2.60±0.37)points in the observation group were lower than those of 63.46％and(2.93±0.41)points in the control group,with a significant difference(P<0.05).After treatment,the observation group patients achieved a significantly higher clinical total effective rate than the control group,with significant differences between groups(χ2=4.981,P=0.026<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(χ2=0.153,P=0.696>0.05).Conclusion The treatment of uremia combined with hyperparathyroidism by calcitriol combined with cinacalcet significantly improves the patient's blood calcium and phosphorus levels,promotes a significant reduction in parathyroid hormone secretion,and thus improves overall clinical efficacy.
万方数据
维普
