Effect analysis of organization of treatment of large area burns in batches
Objective To analyze the treatment effect of large area burns in batches.Methods 19 batches(79 cases)of large-area burn patients with burn area>30％were enrolled in this study,who received fluid infusion,tracheotomy,wound treatment and other treatments.The treatment results were recorded,and the levels of growth factor[vascular endothelial growth factor(VEGF),S100 calcium binding protein A9(S100A9),basic fibroblast growth factor(bFGF)],pain factor[substance P(SP),prostaglandin E2(PGE2),and cyclooxygenase-2(COX-2)]before and after treatment were compared.Results 69 of 79 patients were cured and 10 cases died,of which 4 cases died from wound infection and 2 cases died from severe inhalation injury;1 case died from bleeding from the anonymous artery caused by tracheostomy in the later stage,1 case died from renal failure,1 case died from secondary pneumonia,and 1 case died from catheter-related sepsis.After treatment,VEGF was(265.73±18.49)μg/L,S100A9 was(176.49±10.18)μg/L,bFGF was(274.85±18.63)μg/L,which were higher than those of(110.54±7.63),(80.53±3.12)and(101.52±7.24)μg/L before treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of SP,PGE2 and COX-2 of patients were(46.53±5.11)ng/ml,(124.39±10.67)pg/ml and(53.47±3.42)ng/ml,which were lower than those of(75.29±10.24)ng/ml,(238.74±20.15)pg/ml and(126.79±10.82)ng/ml before treatment,and the difference was statistically significant(t=22.337,44.576,57.429;P=0.000,0.000,0.000<0.05).Conclusion For large area burn patients in batches,the organization of treatment has a significant effect,which is conducive to reducing the degree of pain and regulating the level of growth factors,and can be further promoted in clinical application.
Large area burns in batchesOrganization of treatmentGrowth factorPain factor
万方数据
维普
