Value of pepsinogen Ⅰ/Ⅱ and gastrin combined with routine blood examination in differential diagnosis of atrophic gastritis and gastric cancer
Objective To analyze the value of pepsinogen Ⅰ/Ⅱ and gastrin combined with routine blood examination in differential diagnosis of atrophic gastritis and gastric cancer.Methods 20 patients with gastric cancer were selected as the experimental group 1,50 patients with atrophic gastritis as the experimental group 2,and another 20 healthy subjects as the control group.All subjects in the three groups received pepsinogenⅠ/Ⅱ,gastrin and routine blood examination and gastroscopy.The gastroscopy was used as the gold standard to compare with the results of pepsinogen Ⅰ/Ⅱ and gastrin combined with blood routine examination,and the diagnostic efficacy of pepsinogen Ⅰ/Ⅱ and gastrin combined with blood routine examination was analyzed.The results of pepsinogen Ⅰ/Ⅱ,gastrin and blood routine examination were compared among the three groups,and the cost of pepsinogen Ⅰ/Ⅱ,gastrin combined with routine blood examination and gastroscopy was compared.Results In experimental group 1,the pepsinogen Ⅰ/Ⅱ was(6.21±0.64)and hemoglobin was(101.43±16.02)g/L,which were lower than experimental group 2[(7.45±0.85)and(122.14±17.56)g/L]and control group[(10.25±1.34)and(145.56±18.95)g/L];and the gastrin-17(G-17)was(19.21±2.03)pmol/L and white blood cell count was(12.04±1.34)×109/L,which were higher than experimental group 2[(15.14±1.65)pmol/L and(10.01±1.02)×109/L]and control group[(11.03±1.22)pmol/L and(6.78±0.81)×109/L](P<0.05).The levels of pepsinogen Ⅰ/Ⅱ and hemoglobin in experimental group 2 were lower than those in control group,while gastrin-17 and white blood cell counts were higher than those in control group(P<0.05).The number of positive and negative cases by gastroscopy were 20 and 50 respectively.The number of positive and negative cases by pepsinogen Ⅰ/Ⅱ and gastrin combined with blood routine examination were 19 and 51,respectively.The diagnostic accuracy,sensitivity and specificity were 98.57％,95.00％and 100.00％,respectively.The cost of pepsinogen Ⅰ/Ⅱ and gastrin combined with blood routine examination was(358.79±40.28)yuan,and the cost of gastroscopy was(750.45±100.69)yuan;the cost of pepsinogen Ⅰ/Ⅱ and gastrin combined with blood routine examination was significantly less than that of gastroscopy(t=34.261,P=0.000<0.05).Conclusion PepsinogenⅠ/Ⅱ and gastrin combined with blood routine examination can be used as important indexes for differential diagnosis of atrophic gastritis and gastric cancer,and their diagnostic efficacy is close to that of gastroscopy,which is worthy of application.
Pepsinogen Ⅰ/ⅡGastrinRoutine blood examinationGastroscopeAtrophic gastritisGastric cancer
万方数据
维普
