Objective To investigate the diagnostic value of combined immunoassay in systemic lupus erythematosus.Methods 40 patients with systemic lupus erythematosus were selected as observation group,and they were divided into an observation group 1(non-active phase)and an observation group 2(active phase)according to their activity,with 20 cases in each group.Another 20 cases of health checkups in the same period were selected as the control group.All subjects were tested by combined immunoassay to analyze the diagnostic value.Results The levels of immunoglobulin(Ig)A,IgG and IgM in observation group 2 were higher than those in observation group 1 and control group,while the levels of C3 and C4 were lower than those in observation group 1 and control group(P<0.05).The levels of IgA and IgG in observation group 1 were higher than those in control group(P<0.05),but there was no difference in IgM,C3 and C4 levels between observation group 1 and control group(P>0.05).In the observation group,the positive rate of anti-Sm antibody was 60.00％,the positive rate of anti-histone antibody was 57.50％,the positive rate of anti-double-stranded DNA antibody was 37.50％and the positive rate of anti-nucleosome antibody was 27.50％.In the control group,anti-Sm antibody positive rate was 0,the positive rate of anti-histone antibody was 0,the positive rate of anti-double-stranded DNA antibody was 0,and the positive rate of anti-nucleosome antibody was 0.The positive rates of anti-Sm antibody,anti-histone antibody,anti-double-stranded DNA antibody and anti-nucleosome antibody in the observation group was higher than those in the control group(P<0.05).Conclusion The combined immunoassay is of high value in systemic lupus erythematosus,and can provide reference for its treatment.
关键词
系统性红斑狼疮/免疫学检验/联合检测/诊断价值
Key words
Systemic lupus erythematosus/Immunological test/Joint testing/Diagnostic value
维普
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