Effect analysis of butylphthalide combined with argatroban in the treatment of acute cerebral infarction
Objective To analyze the effect of butylphthalide combined with argatroban in the treatment of acute cerebral infarction(ACI).Methods 88 patients with ACI were randomly divided into an observation group and a control group,with 44 cases in each group.The observation group was treated with butylphthalide+argatroban,and the control group was treated with butylphthalide.Both groups were compared in terms of neurological function indexes[brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),astroglia-derived protein(S100-β)],stromal cell-derived factor-1(SDF-1),visinin-like protein-1(VILIP-1),inflammatory factors[interleukin-6(IL-6)],and tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],treatment effect,and occurrence of adverse reactions.Results After treatment,the observation group had higher BDNF of(5.58±0.37)ng/ml than(4.35±0.58)ng/ml in the control group,and lower NSE of(20.37±6.48)μg/L and S100-β of(0.28±0.07)μg/L than(33.71±8.62)and(0.41±0.12)μg/L in the control group.There was statistical significance between the two groups(P<0.05).After treatment,the observation group had higher SDF-1 of(3053.47±182.56)pg/ml than(2863.52±142.60)pg/ml in the control group,and lower VILIP-1 of(542.26±91.31)pg/ml than(582.73±78.65)pg/ml in the control group.There was statistical significance between the two groups(P<0.05).After treatment,IL-6,TNF-α and hs-CRP in the observation group were(13.74±2.24)ng/L,(24.17±5.71)ng/L and(6.40±1.51)mg/L,which were lower than(17.62±2.53)ng/L,(30.62±4.27)ng/L and(8.37±1.28)mg/L in the control group,and the comparison between groups was statistically significant(P<0.05).The total effective rate of the observation group was 95.45％,which was higher than 81.82％of the control group,and the comparison between the two group was statistically significant(P<0.05).The incidence of adverse reactions was 9.09％in the observation group and 13.64％in the control group,with no statistical significance between the two groups(P>0.05).Conclusion The combination of butylphthalide and argatroban in the treatment of ACI can effectively improve the neurological indicators and the level of inflammatory factors of patients,and improve the efficacy.
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