Objective To analyze the effect of butylphthalide combined with argatroban in the treatment of acute cerebral infarction(ACI).Methods 88 patients with ACI were randomly divided into an observation group and a control group,with 44 cases in each group.The observation group was treated with butylphthalide+argatroban,and the control group was treated with butylphthalide.Both groups were compared in terms of neurological function indexes[brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),astroglia-derived protein(S100-β)],stromal cell-derived factor-1(SDF-1),visinin-like protein-1(VILIP-1),inflammatory factors[interleukin-6(IL-6)],and tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],treatment effect,and occurrence of adverse reactions.Results After treatment,the observation group had higher BDNF of(5.58±0.37)ng/ml than(4.35±0.58)ng/ml in the control group,and lower NSE of(20.37±6.48)μg/L and S100-β of(0.28±0.07)μg/L than(33.71±8.62)and(0.41±0.12)μg/L in the control group.There was statistical significance between the two groups(P<0.05).After treatment,the observation group had higher SDF-1 of(3053.47±182.56)pg/ml than(2863.52±142.60)pg/ml in the control group,and lower VILIP-1 of(542.26±91.31)pg/ml than(582.73±78.65)pg/ml in the control group.There was statistical significance between the two groups(P<0.05).After treatment,IL-6,TNF-α and hs-CRP in the observation group were(13.74±2.24)ng/L,(24.17±5.71)ng/L and(6.40±1.51)mg/L,which were lower than(17.62±2.53)ng/L,(30.62±4.27)ng/L and(8.37±1.28)mg/L in the control group,and the comparison between groups was statistically significant(P<0.05).The total effective rate of the observation group was 95.45％,which was higher than 81.82％of the control group,and the comparison between the two group was statistically significant(P<0.05).The incidence of adverse reactions was 9.09％in the observation group and 13.64％in the control group,with no statistical significance between the two groups(P>0.05).Conclusion The combination of butylphthalide and argatroban in the treatment of ACI can effectively improve the neurological indicators and the level of inflammatory factors of patients,and improve the efficacy.
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