摘要
目的 探讨老年冠心病患者应用阿司匹林和氯吡格雷的治疗效果及安全性.方法 60 例老年冠心病患者,随机分为研究组与对照组,每组 30 例.对照组给予阿司匹林治疗,研究组在对照组基础上联合服用氯吡格雷治疗.对比两组临床疗效、不良反应发生情况及血小板功能指标[血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)].结果 研究组治疗总有效率(96.67％)较对照组(80.00％)更高,对比有统计学意义(P<0.05).研究组PLT、MPV、PCT分别为(126.78±37.29)×109/L、(8.45±0.64)fl、(0.28±0.07)％,较对照组的(158.63±35.41)×109/L、(10.24±1.03)fl、(0.34±0.04)％明显更低,差异有统计学意义(P<0.05).研究组不良反应发生率(3.33％)较对照组(23.33％)更低,差异有统计学意义(P<0.05).结论 阿司匹林和氯吡格雷治疗老年冠心病患者临床疗效及安全性更高,值得临床借鉴.
Abstract
Objective To discuss the effect and safety of aspirin and clopidogrel in the treatment of coronary heart disease in the elderly.Methods 60 elderly patients with coronary heart disease were randomly divided into a study group and a control group,with 30 cases in each group.The control group was treated with aspirin,and the study group was treated with clopidogrel based on the control group.The clinical efficacy,occurrence of adverse reactions and platelet function indexes[platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT)]of the two groups were compared.Results The total effective rate of the study group(96.67％)was higher than the control group(80.00％),and the comparison was statistically significant(P<0.05).The PLT,MPV and PCT of the study group were(126.78±37.29)×109/L,(8.45±0.64)fl and(0.28±0.07)％,respectively,which were significantly lower than(158.63±35.41)×109/L,(10.24±1.03)fl,(0.34±0.04)％in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group(3.33％)was lower than the control group(23.33％),and the difference was statistically significant(P<0.05).Conclusion Aspirin and clopidogrel have higher clinical efficacy and safety in the treatment of elderly patients with coronary heart disease,which is worthy of clinical reference.
维普
万方数据