Study on the pharmaceutical value of ambroxol hydrochloride in pediatric pneumonia by different modes of administration
Objective To investigate the effect of ambroxol hydrochloride in pediatric pneumonia by different modes of administration.Methods 100 children with pneumonia were divided into a control group and an observation group according to random number table method,with 50 cases in each group.Both groups were treated with ambroxol hydrochloride,which was administered by intravenous drip in the control group and by aerosol inhalation in the observation group.Both groups were compared in terms of treatment effect,symptom resolution time,hospitalization time,inflammatory factors[C-reactive protein(CRP),interleukin-2(IL-2)and interleukin-6(IL-6)],blood gas indicators[arterial partial pressure of carbon dioxide(PaCO2)and arterial partial pressure of oxygen(PaO2),and oxygenation index(PaO2/FiO2)],and occurrence of adverse reactions.Results The total effective rate of 96.00％in the observation group was higher than that of 84.00％in the control group,and the difference was statistically significant(χ2=4.0000,P=0.0455<0.05).The duration of fever and cough,moist rale disappearance time and hospitalization time in the observation group were(1.89±0.23),(5.12±0.36),(5.32±1.56)and(6.12±2.05)d,which were shorter than those of(3.32±1.28),(6.69±1.79),(6.98±1.55)and(8.79±2.15)d in the control group,and the difference was statistically significant(P<0.05).After treatment,CRP of(3.56±1.00)mg/L and IL-6 of(73.56±11.56)ng/L in the observation group were lower than those of(10.55±5.18)mg/L and(108.65±33.69)ng/L in the control group;and IL-2 of(34.25±5.69)ng/L in the observation group was higher than that of(26.58±6.79)ng/L in the control group;and the difference was statistically significant(P<0.05).After treatment,PaCO2 of(31.05±5.36)mm Hg(1 mm Hg= 0.133 kPa)in the observation group was lower than that of(34.89±7.15)mm Hg in the control group;and PaO2 of(93.65±8.15)mm Hg and PaO2/FiO2 of(197.58±48.52)mm Hg were higher than those of(82.15±7.48)and(172.56±44.79)mm Hg in the control group;and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions in the observation group(2.00％)compared with the control group(4.00％)(χ2=0.3436,P=0.5577>0.05).Conclusion The efficacy of ambroxol hydrochloride in the treatment of pediatric pneumonia is different in different modes of administration.The treatment of ambroxol hydrochloride by aerosol inhalation is more effective and safe,which is worthy of clinical use and promotion.
Pediatric pneumoniaAmbroxol hydrochlorideAerosol inhalationPharmaceutical value
万方数据
维普
