Observation on effect of Yangzheng Mixture on immune status and side effects in patients with colorectal cancer undergoing XELOX chemotherapy
Objective To explore the effect of Yangzheng Mixture on immune status and side effects in patients with colorectal cancer undergoing XELOX chemotherapy.Methods The clinical data of 85 patients with colorectal cancer undergoing XELOX chemotherapy was retrospectively analyzed.According to presence or absence of Yangzheng Mixture intervention,they were divided into routine intervention group(39 cases)and modified intervention group(46 cases).The routine intervention group received routine nutrition support combined with rapid rehabilitation nursing,and the modified intervention group was combined with Yangzheng Mixture on the basis of the routine intervention group.The levels of cellular immune function indicators(CD3+,CD4+,CD4+/CD8+),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199)and side effects were compared between the two groups before and after intervention.Results After intervention,the levels of CD3+,CD4+and CD4+/CD8+in both groups were higher than those before intervention;and CD3+of(67.21±7.89)％,CD4+of(46.89±8.45)％and CD4+/CD8+of(1.89±0.54)in modified intervention group were higher than those of(61.13±7.45)％,(40.12±5.26)％and(1.46±0.39)in routine intervention group(P<0.05).After intervention,the levels of CEA,CA125 and CA199 were decreased in both groups compared to those before intervention;and CEA of(5.26±1.56)μg/L,CA125 of(29.17±5.23)U/ml and CA199 of(32.75±5.36)U/ml in modified intervention group were lower than those of(8.14±1.38)μg/L,(35.46±6.14)U/ml and(38.46±6.14)U/ml in routine intervention group(P<0.05).The incidence of side effects in modified intervention group was 28.26％,which was significantly lower than that of 53.85％in routine intervention group(P<0.05).Conclusion The application of Yangzheng Mixture in XELOX chemotherapy can effectively improve the immune function of colorectal cancer patients after chemotherapy,improve the efficacy of chemotherapy while alleviating side effects,which has high application value and is worthy of clinical reference.
万方数据
维普
