Clinical study of Juadu Huazhuo Yishen Decoction for prevention of chemotherapy-related ovarian function injury in young breast cancer patients
Objective To evaluate the effect of Juadu Huazhuo Yishen Decoction for prevention of chemotherapy-related ovarian function injury in young breast cancer patients.Methods 63 young patients with pathologically confirmed breast cancer were divided into a treatment group(31 cases)and a control group(32 cases)by random number table method.The control group received chemotherapy alone,and the treatment group was combined with Juadu Huazhuo Yishen Decoction during chemotherapy.The menstrual status,perimenopausal symptoms,levels of estradiol(E2),follicle stimulating hormone(FSH)and incidence of low anti-Mullerian hormone(AMH)were compared between the two groups after chemotherapy.Results The treatment group had a normal menstrual cycle rate of 29.03％,a menstrual bleeding reduction rate of 54.84％,and an amenorrhea rate of 16.13％after chemotherapy.The control group had a normal menstrual cycle rate of 12.50％,a menstrual bleeding reduction rate of 43.75％,and an amenorrhea rate of 43.75％after chemotherapy.There was a statistically significant difference in menstrual changes between the two groups after chemotherapy(P<0.05).The occurrence of amenorrhea in the treatment group was(4.40±1.14)months after chemotherapy,which was later than(2.50±0.94)months in the control group,with significant difference(P<0.05).After chemotherapy,22.58％of patients in the treatment group and 50.00％in the control group had perimenopausal symptoms;the proportion of patients with perimenopausal symptoms after chemotherapy was statistically different between the two groups(P<0.05).Before chemotherapy,there were no significant differences in serum E2[(49.65±15.27)pg/ml VS(46.06±12.99)pg/ml]and FSH[(6.15±1.78)U/L VS(5.93±1.55)U/L]between treatment group and control group(P>0.05).At 6 months after chemotherapy,the serum E2 level was(27.01±7.89)pg/ml and serum FSH level was(21.94±10.54)U/L in the treatment group;in the control group,the serum E2 level was(19.64±8.55)pg/ml and the serum FSH level was(32.91±17.81)U/L.The decrease level of serum E2 and the increase level of serum FSH in the treatment group were less than those in the control group,and the difference was statistically significant(P<0.05).The incidence of low AMH at 1 year after chemotherapy was 35.48％(11/31)in the treatment group and 62.50％(20/32)in the control group,and the difference between the two groups was statistically significant(χ2=4.598,P=0.032<0.05).Conclusion Juadu Huazhuo Yishen Decoction during chemotherapy in young breast cancer patients has a protective effect on ovarian function,which can reduce the incidence of menstrual disorders and amenorrhea,the incidence of perimenopausal symptoms and the incidence of serum low AMH,inhibit the decrease of serum E2,and promote the increase of FSH.
Traditional Chinese medicineJuadu Huazhuo Yishen DecoctionBreast cancerOvarian functionChemotherapy
万方数据
维普
