Effects of dynamic resistance exercise training on renal function,microinflammatory state,and quality of life in patients with non-dialysis chronic kidney disease
Objective To explore the effects of dynamic resistance exercise training on renal function,microinflammatory state,and quality of life in patients with non-dialysis chronic kidney disease(CKD).Methods 80 non-dialysis CKD patients were divided into a control group and an intervention group using a random number grouping method,with 40 patients in each group.The control group received routine exercise training,while the intervention group received dynamic resistance exercise training.Comparison was made on renal function[serum creatinine(SCr),blood urea nitrogen(BUN),endogenous creatinine clearance rate(CCr)],microinflammatory state[C-reactive protein(CRP),interleukin-6(IL-6)],quality of life[generic quality of life inventory-74(GQOLI-74)score],exercise status[6-min walking test distance],and psychological status[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)scores]between the two groups.Results At the end of exercise,the levels of SCr,BUN and CCr in both groups were lower than those before exercise in this group(P<0.05);the intervention group had SCr of(332.81±23.69)μmol/L,BUN of(17.54±3.69)mmol/L,CCr of(15.51±2.28)ml/min,which were lower than those of(371.32±23.87)μmol/L,(19.33±2.65)mmol/L,(19.63±2.24)ml/min in the control group(P<0.05).At the end of exercise,the levels of CRP and IL-6 in both groups were lower than those before exercise in this group(P<0.05);CRP of(18.73±3.87)mg/L and IL-6 of(48.63±2.41)ng/L in the intervention group were lower than those of(30.15±3.95)mg/L and(70.57±2.69)ng/L in the control group(P<0.05).At the end of exercise,GQOLI-74 score in both groups was higher than that before exercise in this group(P<0.05),and 6MWT distance was longer than that before exercise in this group(P<0.05);GQOLI-74 score of(72.73±3.87)points in the intervention group was higher than that of(64.15±3.95)points in the control group(P<0.05);6MWT distance of(398.63±12.41)m in the intervention group was longer than that of(370.57±12.69)m in the control group(P<0.05).At the end of exercise,the scores of SAS and SDS in both groups were lower than those before exercise in this group(P<0.05);SAS score of(19.74±2.06)points and SDS score of(18.69±1.12)points in the intervention group were lower than those of(29.63±2.01)and(23.55±1.04)points in the control group(P<0.05).Conclusion Application of dynamic resistance exercise training in non-dialysis chronic kidney disease can improve renal function and microinflammatory state of patients,improve quality of life and exercise ability,and reduce negative psychology of patients.
Dynamic resistance exercise trainingNon-dialysisChronic kidney diseaseRenal functionMicroinflammatory stateQuality of life
万方数据
维普
