Research progress of guanylate cyclase activator vericiguat in the treatment of heart failure
With the deepening of research on the pathogenesis and treatment of heart failure,in recent years,many new drugs have replaced the traditional treatment concept of heart failure of"cardiotonic,diuretic,vasodilator",and have adopted neuroendocrine regulation as the theoretical basis of the therapeutic drugs.Vericiguat is a novel soluble guanylate cyclase activator.It can also increase the concentration of cGMP in cardiomyocytes through the nitric oxide(NO)-soluble guanylate cyclase(sGC)-cyclic guanosine monophosphate(cGMP)pathway,thereby playing a role in the treatment of chronic heart failure.Vericiguat is also helpful in the treatment of heart failure complications such as chronic kidney disease(CKD).At present,vericiguat is gradually becoming a popular drug in the treatment of heart failure.This paper reviews the research progress,mechanism of action and prospect of clinical application of vericiguat.
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维普
