Clinical effect of combined treatment of Shuxuetong injection and clopidogrel in elderly patients with acute cerebral infarction
Objective To analyze the effect of combined treatment of Shuxuetong injection and clopidogrel in elderly patients with acute cerebral infarction.Methods 150 elderly patients with acute cerebral infarction were selected as the subjects of this study.They were divided into an observation group and a control group according to random numerical table,each with75 cases.The control group was treated with clopidogrel,while the observation group was treated with Shuxuetong injection and clopidogrel.Both groups were compared in terms of clinical effects,neurological function[National Institutes of Health Stroke Scale(NIHSS)score],self-care ability[Barthel index(BI)score],serum inflammatory mediator[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]and hemorheology indicators(whole blood high-shear viscosity,whole blood low-shear viscosity,plasma viscosity,fibrinogen)before and after treatment,and incidence of adverse reactions.Results The total effective rate of treatment in the observation group was 96.00%,which was higher than 86.67%in the control group,and the difference was significant(χ2=4.127,P=0.042<0.05).After treatment,the NIHSS score in both groups was lower than that before treatment,and BI score was higher than that before treatment;NIHSS score of(12.30±1.23)points in the observation group was lower than(24.61±1.80)points in the control group,and BI score of(81.45±8.27)points was higher than(74.39±7.46)points in the control group;the difference was significant(P<0.05).The incidence of adverse reactions of 5.33%in the observation group was lower than 8.00%in the control group,but the difference was not significant(P>0.05).After treatment,the levels of IL-6,IL-8 and TNF-α were decreased in both groups;and the levels of IL-6,IL-8 and TNF-α in the observation group were(3.86±1.03)ng/ml,(0.06±0.05)pg/ml and(138.62±26.31)pg/ml,which were lower than(4.69±1.05)ng/ml,(0.11±0.08)pg/ml and(351.62±29.62)pg/ml in the control group;the difference was significant(P<0.05).After treatment,the whole blood high-shear viscosity,whole blood low-shear viscosity,plasma viscosity and fibrinogen decreased in both groups;in the observation group,the whole blood high-shear viscosity,whole blood low-shear viscosity,plasma viscosity and fibrinogen were(4.92±0.81)mPa·s,(9.92±0.78)mPa·s,(1.62±0.11)mPa·s and(3.03±0.03)g/L,which were lower than(6.18±0.89)mPa·s,(10.91±0.81)mPa·s,(1.71±0.17)mPa·s and(4.58±0.07)g/L in the control group;the difference was significant(P<0.05).Conclusion The combined use of Shuxuetong injection and clopidogrel in the treatment of elderly patients with acute cerebral infarction has significant clinical effects,which can improve their daily living ability and neurological function,and correct the level of serum inflammatory mediators,with high safety.It can promote the rehabilitation of patients,and is worthy of promotion and-application.
Acute cerebral infarction in the elderlyShuxuetong injectionClopidogrelNeurological functionSelf care ability
万方数据
维普
