Effect of escitalopram on mental state of patients with post-cerebral infarction depression
Objective To explore the the clinical efficacy of escitalopram treatment in patients with post-cerebral infarction depression(PCID).Methods A total of 92 PCID patients as study subjects were divided into a control group and an observation group by odd-even method,with 46 cases in each group.Both groups received conventional symptomatic treatment for cerebral infarction,the control group was treated with flupentixol melitracen,and the observation group was treated with escitalopram.The neurological function,mental state,neurotransmitter and clinical effect of the two groups were compared.Results The total effective rate of 97.83%in the observation group was higher than 80.43%in the control group(P<0.05).After treatment,the scores of Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)in the observation group were(4.12±0.12)and(4.11±0.36)points,which were lower than(7.36±0.65)and(7.63±1.23)points in the control group;and the score of Mini-Mental State Examination(MMSE)of(26.25±3.15)points in the observation group was higher than(23.15±1.24)points in the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score of(4.12±0.13)points in the observation group was lower than(6.12±0.52)points in the control group,and Barthel index(BI)score of(76.49±4.62)points was higher than(72.25±2.36)points in the control group(P<0.05).After treatment,the scores of feeding,bathing,grooming,dressing,stool control,urination control,toilet use,bed chair transfer,flat walking and stairs were(8.56±0.36),(8.69±0.45),(8.69±0.63),(8.78±0.46),(8.82±0.15),(8.96±0.32),(8.88±0.25),(9.11±0.56),(8.68±0.46)and(8.89±0.47)points in the observation group,which were higher than(7.69±0.65),(7.71±0.33),(7.63±0.34),(7.89±0.34),(7.25±0.64),(8.12±0.11),(7.96±0.15),(7.86±0.13),(7.89±0.31)and(7.86±0.36)points in the control group(P<0.05).The incidence of adverse reactions of 2.17%in the observation group was lower than 17.39%in the control group(P<0.05).Conclusion On the basis of conventional symptomatic treatment for cerebral infarction,escitalopram in the treatment of PCID patients has significant effects,which can rapidly improve the neurological function of patients,improve their activities of daily living,relieve anxiety and depression symptoms,and improve cognitive function of patients.It has high drug safety.
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