Study on the effect of dydrogesterone combined with progesterone on the success of fetal preservation,hormone level,neonatal birth index and curative effect and safety of threatened abortion
Objective To explore the effect of dydrogesterone combined with progesterone on the success of fetal preservation,hormone level,neonatal birth index and curative effect and safety of threatened abortion.Methods A total of 100 patients with threatened abortion were divided into a control group and an observation group by random number table,with 50 cases in each group.The control group was treated with dydrogesterone,and the observation group was treated with dydrogesterone and progesterone.The success of fetal preservation,hormone[estradiol(E2),progesterone(P),human chorionic gonadotropin(HCG)]level,neonatal index(neonatal weight,neonatal malformation rate),the treatment effect and the occurrence of adverse reactions were compared between the two groups.Results The success rates of fetal preservation in the observation group was 88.00%,which was higher than 70.00%in the control group,with a significant difference(P<0.05).After treatment,the E2,P and HCG levels increased in both groups,and E2,P and HCG levels in the observation group were(1078.41±18.26)pg/ml,(31.86±3.66)nmol/L and(8574.21±96.69)U/ml,which were higher than(905.25±26.69)pg/ml,(25.91±4.13)nmol/L and(7410.33±105.53)U/ml in the control group.The difference was significant(P<0.05).The neonatal weight in the control group was(3259.87±84.91)g,with 0 case of neonatal malformations;the neonatal weight in the observation group was(3275.46±86.29)g,with 1 case(2.00%)of neonatal malformation.There was no significant difference in neonatal weight and neonatal malformation rate between the two groups(P>0.05).The total effective rate of 96.00%in the observation group was higher than 84.00%in the control group,with a significant difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of dydrogesterone and progesterone in the treatment of threatened abortion patients can achieve prominent effect,which is beneficial to improve the success rate of fetal preservation,improve the level of various hormones,and will not affect the neonatal birth index,and has high safety.It is recommended to be widely used in clinical practice.
DydrogesteroneProgesteroneThreatened abortionSuccess of fetal preservationHormone levelNeonatal birth index
万方数据
维普
