Predictive value of CTRP3 combined with NT-proBNP for HHcy in patients with MVD
Objective To investigate the predictive value of complement-C1q/tumor necrosis factor related protein-3(CTRP3)combined with N-terminal pro-B-type natriuretic peptide(NT-proBNP)for hyperhomocysteinemia(HHcy)in patients with coronary multi-vessel disease(MVD).Methods A retrospective analysis was performed on clinical data of 200 patients with coronary MVD.Patients were divided into high Hcy group(111 cases)and normal Hcy group(89 cases)according to whether plasma homocysteine(Hcy)level>15 μmol/L or not.Both groups were compared in terms of baseline data[age,sex,duration of coronary heart disease,smoking history,history of diabetes mellitus,history of hypertension,and body mass index(BMI)]and biochemical indicators[NT-proBNP,uric acid(UA),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),Hcy,CTRP3].Binary Logistic regression analysis was used to analyze the risk factors affecting HHcy in MVD patients,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of CTRP3 combined with NT-proBNP on HHcy in MVD patients.Results There were no significant differences in age,history of hypertension,BMI,UA,TG,TC and HDL-C between the two groups(P>0.05).The number of male patients in the high Hcy group was 70 cases,the duration of coronary heart disease was(6.66±4.49)years,55 cases had a smoking history and 60 cases had a history of diabetes mellitus,which were higher than 36 cases,(3.67±2.31)years,28 cases and 17 cases in the normal Hcy group;NT-proBNP in the high Hcy group was(5234.95±7476.76)pg/ml,LDL-C was(3.55±0.95)mmol/L and Hcy was(44.75±12.48)μmol/L,which were higher than(1296.94±3864.78)pg/ml and(2.95±0.88)mmol/L L,(10.58±2.80)μmol/L in normal Hcy group;CTRP3 of(65.20±13.61)μg/L in the high Hcy group was lower than(88.69±14.94)μg/L in normal Hcy group;the difference between the two groups was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that male[OR=3.745,95%CI=(1.398,10.030)],history of diabetes mellitus[OR=3.262,95%CI=(1.264,8.417)],duration of coronary heart disease[OR=1.194,95%CI=(1.022,1.394)]and LDL-C[OR=2.254,95%CI=(1.337,3.800)]were independent risk factors for HHcy in MVD patients,while CTRP3[OR=0.902,95%CI=(0.873,0.933)]was an independent protective factor(P<0.05).Conclusion Sex,history of diabetes mellitus,duration of coronary heart disease and LDLC are independent risk factors for HHcy in MVD patients;while CTRP3 is an independent protective factor.Serum CTRP3 combined with NT-proBNP can improve the predictive value of HHcy in MVD patients.
Coronary multi-vessel diseaseHyperhomocysteinemiaN-terminal pro-B-type natriuretic peptideComplement-C1q/tumor necrosis factor related protein-3Predictive value
万方数据
维普
