Analysis of clinical efficacy and adverse reactions of goserrelin acetate sustained-release depot combined with mifepristone in the treatment of uterine fibroids
Objective To analyze the effect and adverse reactions of goserrelin acetate sustained-release depot combined with mifepristone in the treatment of uterine fibroids.Methods 80 patients with uterine fibroids were divided into a control group and a study group according to random number table method,with 40 cases in each group.The control group was treated with goserrelin acetate sustained-release depot,and the study group was treated with goserrelin acetate sustained-release depot and mifepristone.Comparison was made on clinical efficacy,hemorheological indexes(plasma viscosity,erythrocyte aggregation index,fibrinogen),sex hormone indexes[luteinizing hormone(LH),estradiol(E2),follicle stimulating hormone(FSH)],uterine fibroid volume,and the occurrence of adverse reactions between the two groups.Results The total effective rate of 95.00%in the study group was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the plasma specific viscosity in the study group was(0.89±0.20),the fibrinogen was(2.13±0.34)g/L and the erythrocyte aggregation index was(48.78±6.99)%,which were lower than(1.65±0.30),(3.97±0.64)g/L and(64.12±7.34)%in the control group.The difference was statistically significant(P<0.05).After treatment,the study group had LH of(10.64±2.96)U/L,E2 of(138.78±18.32)pmol/L,FSH of(11.97±2.86)U/L,which were lower than(13.52±2.81)U/L,(200.23±36.56)pmol/L,(17.15±4.33)U/L in the control group,and the difference was statistically significant(P<0.05).After treatment,the uterine fibroid volume of(5.24±1.01)cm3 in the study group was smaller than(11.63±1.78)cm3 in the control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of adverse reactions was 15.00%in the study group and 7.50%in the control group,and there was no statistical significance between the two groups(P>0.05).Conclusion The combination of mifepristone and goserrelin acetate sustained-release depot in the treatment of uterine fibroids has a good effect,which can improve the hemorheology level of patients,adjust their sex hormone indexes,effectively shrink the uterine fibroid volume of patients,and promote their early recovery.It has certain clinical application and research value.
万方数据
维普
