The effect of probiotics on symptoms,medication use,and quality of life in children with dust mite allergic rhinitis
Objective To investigate the effect of probiotics on symptoms,medication use,and quality of life in children with dust mite allergic rhinitis(AR).Methods A total of 115 child patients with allergic AR caused by dust mites as study subjects were divided into the conventional group(58 cases)and the probiotic group(57 cases)according to different treatment methods.The conventional group was treated with conventional intervention,while the probiotic group was treated with probiotics on the basis of the conventional group.The subjective visual analogue scale(VAS)score,medication score,and rhinoconjunctivitis quality of life questionnaire(RQLQ)score,and nasal symptom score of the two groups of children were compared at different time points[before treatment(T0),6 months after treatment(T1),and 6 months after discontinuation of medication(T2)].Results At T0,the VAS score,medication score,and RQLQ score of the conventional group were(5.97±2.01),(1.64±1.06),and(2.04±0.72)points,respectively;at T1,they were(2.79±1.07),(0.71±0.44),and(1.69±0.93)points,respectively;at T2,they were(2.48±0.99),(0.58±0.49),and(1.71±0.93)points,respectively.At T0,the VAS score,medication score,and RQLQ score of the probiotic group were(6.18±1.94),(1.71±1.09),and(2.01±0.73)points,respectively;at T1,they were(2.05±0.78),(0.49±0.45),and(1.37±0.67)points,respectively;at T2,they were(2.21±0.81),(0.54±0.45),and(1.58±0.72)points,respectively.The VAS score,medication score and RQLQ score at T1 and T2 of the two groups were lower than those at T0;and the VAS score,medication score and RQLQ score at T1 of the probiotic group were lower than those of the conventional group;the difference was statistically significant(P<0.05).There were no significant differences in the VAS score,medication score and RQLQ score between the two groups at T0 and T2(P>0.05).At T0,the scores for nasal congestion,nasal itching,sneezing,and runny nose in the conventional group were(1.81±0.66),(1.60±0.62),(1.68±0.77),and(1.34±0.69)points,respectively;at T1,they were(0.95±0.53),(0.87±0.49),(0.90±0.56),and(0.96±0.46)points,respectively;at T2,they were(0.93±0.54),(0.84±0.43),(0.88±0.31),and(0.89±0.54)points,respectively.At T0,the scores for nasal congestion,nasal itching,sneezing,and runny nose in the probiotic group were(1.78±0.57),(1.63±0.61),(1.70±0.70),and(1.41±0.69)points,respectively;at T1,they were(0.75±0.45),(0.72±0.23),(0.70±0.43),and(0.78±0.50)points,respectively;at T2,they were(0.91±0.43),(0.83±0.51),(0.86±0.53),and(0.85±0.50)points,respectively.The scores for nasal congestion,nasal itching,sneezing and runny nose at T1 and T2 of the two groups were lower than those at T0,and the scores of probiotic group at T1 were lower than those of conventional group.The difference was statistically significant(P<0.05).There were no significant differences in scores for nasal congestion,nasal itching,sneezing and runny nose between the two groups at T0 and T2(P>0.05).Conclusion Appropriate use of probiotics for child patients with dust mite allergic AR is conducive to alleviating the symptoms of children,improving their quality of life,reducing the use of drugs.The effect is time-dependent.
万方数据
维普
