Study on clinical effect of diazepam combined with phenobarbital in children with convulsion
Objective To observe the clinical effect of diazepam combined with phenobarbital in children with convulsion.Methods 84 children with convulsion were randomly divided into a control group and an observation group,with 42 cases in each group.Both groups were given conventional treatment.On this basis,the control group was treated with diazepam,and the observation group was treated with diazepam combined with phenobarbital.The therapeutic effect,occurrence of adverse events,serum indicators before and after treatment,prognosis and immune function indicators after treatment were compared between the two groups.Results The total effective rate of 95.24%in the observation group was higher than 80.95%in the control group(P<0.05).After treatment,the brain-derived neurotrophic factor(BDNF)of(16.58±0.38)μg/L in the observation group was higher than(12.26±1.05)μg/L in the control group;and NSE of(20.01±2.09)ng/ml and S100-β of(0.15±0.01)μg/L in the observation group were lower than(31.24±2.08)ng/ml and(0.29±0.02)μg/L in the control group(P<0.05).The cumulative frequency of convulsions in the observation group were(0.45±0.05)and(1.01±0.15)times after 6 and 12 months of treatment,which were lower than(1.45±0.11)and(2.41±0.15)times in the control group(P<0.05).The observation group had immunoglobulin(Ig)A of(0.82±0.07)g/L,IgM of(0.61±0.10)g/L,IgG of(6.11±0.48)g/L and CD8+ of(0.20±0.01)%,which were lower than(0.90±0.10)g/L,(0.94±0.15)g/L,(7.84±0.42)g/L and(0.27±0.02)%in the control group;and CD4+ of(41.75±2.05)%and CD4+/CD8+ of(1.95±0.18)in the observation group were higher than(39.46±0.12)%and(1.75±0.14)in the control group(P<0.05).The incidence of adverse events in the observation group was slightly higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion The implementation of diazepam combined with phenobarbital therapy in children with convulsion can improve the clinical therapeutic effect,improve the nervous system function of children,and enhance the safety of drug therapy,which is worthy of promotion.
Convulsion in childrenDiazepamPhenobarbitalNeurological function
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维普
